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Nootropil

See also Piracetam

Roman name

Nootropil

Characteristics

Cycles derivative GABA.

Pharmacokinetics

Once inside quickly and almost completely absorbed, reaching peak concentrations after one hour after administration. Bioavailability of approximately 100%. After receiving a single dose of 2 g C_max (40-60 µ g / ml) in the blood is achieved within 30 min in spinal fluid for a period of 2-8 hours Apparent volume of 0.6 l / mm Passes through GEB, placental barrier and membranes used in gemodialise. Selectively accumulate in the tissues of cortex in the brain, mostly in leading, and temennykh spine shares, in the cerebellum and bazalnah gangliah. It is associated with blood plasma proteins, and not biotransformation. Provided kidney in an unmodified form. Renal excretion 95% rate imposed in 30 minutes. Kidney klirens healthy volunteers-86 ml / min. T_1/2 from blood plasma-4-5 hours of spinal fluid 6-8 hours (longer for kidney failure). There has been change farmakokineticeskih parameters in patients with liver failure.

Farmakodinamika

The direct effects on the brain improves cognitive (learning) processes, such as the ability to learn, memory, attention, as well as mental fitness. Has impact on the central nervous system in various ways : izmenenaa speed of initiation in the brain, improving metabolic processes in the nerve cells and microcirculation, affecting not gemoreologicakie characteristics (no sosudorasshiratego action). Ingibiruet agregatia platelets and restores configuration properties of the outer membrane rigidnykh cells, as well as the ability of the latter to passaju through receptacles microcirkulatornogo Rusla.okazavaet protective and restorative effect on the human brain as a result of hypoxia and intoxication, as well as post-shock therapy. When the blood or acute cerebral Ischemia in patients with brain increasing local consumption of oxygen and glucose. Decreases the severity and duration of vestibular nystagmic.

Indications

Treating symptoms Psycho syndrome, in particular for older persons suffering from declining memory golovokrugeniem, decreased concentration, as well as the overall activity, changing mood disorder behaviour and boundaries between individual human gait, as well as in patients with Alzheimer's Disease and senilna alzgeimerovsky brain type with dementia because of repeated violations tank кровообращения.Лечен��е ishemicski stroke and its consequences, such as mental and physical disorders, speech disorders, the slowdown, violations emotional Sfera.pri treatment (and recovery) Vascular, toxic and traumatic encephalopathy, the deficit in the recognition of head injuries (from golovokrugeniem and without). Treatment of withdrawal and Psycho syndrome with chronic Alkilizme.lechenie dizziness and related disorders balance, with the exception of dizziness vazomotonego and mental Proishojdenia.dl correction low learning of writing for children, especially in cases of diminished mental capacity, recognizing text, that can not be explained disorder intelligence, insufficient training or complex family Usloviami.dl treatment mioclonii BGs, as a means alone or in combination with other Preparatami.v treatment of sickle-cell anaemia.

Pregnancy and lactation

Except in special circumstances Nootropil not be appointed during pregnancy and lactation. As in the case of other drugs it is necessary to assess the possible positive effects of the appointment Nootropila over I trimester of pregnancy and lactation period.

Contraindications

Гиперчувствительност ь (including derivatives pirrolidona), the acute cerebral circulation (haemorrhagic stroke) expressed renal insufficiency (Cl creatinine below 20 ml / min), children up to 1 year.

Side-Effects

Giperkinesia, increased body mass index, irritability, drowsiness, depression, fatigue (can be observed in older patients receiving doses of more than 2.4 g / sut.). In most cases, unable to regress similar symptoms, reducing dose of the drug. Some patients Slabostj.imeutxia a few reports of side effects from the stomach (nausea, vomiting, diarrhoea, pain in the abdomen) or nausea, and headaches, raising sexuality tremore, skin reactions гиперчувствительност и.

Patient interaction

Together with the admission of hormone the thyroid gland had been only one case of confusion, excitement of the Sna.ne interaction with clonazepam, fenitoinom, fenobarbitalom, valproatom Natria.pri a 9.6 g / day pyracetam patients receiving treatment atenokumarolom about venous thrombosis observed lower levels of aggregation platelets, the level fibrinoguena factors Villebranda, viscosity of blood and plasma, as in the appointment of �ценокумарола.Возможн о interaction with the media, central nervous system stimulant, antipsychotic drugs (Increased �иперкинезии).Совмест��ый Reception 1.6 g pyracetam with alcohol does not affect the concentration of pyracetam and alcohol in the blood serum.

Overdosing

Doses of the drug to 400 µ g / kg / day known as a carry. Is non-toxic drug, so if you overdose no special measures. Recommended : rinsed stomach, a gray vomiting, the activated carbon. Specific antidote not. Treatment of symptoms, which may include Hepatology (the latter is 50-60%), perhaps a big diureza (oral or intravenous drugs)

Precautions

The caution should be appointed to patients in violation of hemostasis during big surgery, or patients with symptoms of heavy bleeding (due to the influence of the pyracetam agregatia platelets). Patients BGs mioclauniei dramatic interruption of treatment can lead to a resumption of Pristupov.s use caution during the drivers of vehicles and people profession involve heightened concentration.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

5 years

The registration

011926/01-2000

The drug forms

Capsules 400 mg : white / white capsules marked ucb / N; table. 800 and 1200 mg : white, oval, thickly coated with a mark midway marked N / N; 20% solution for the reception inside : colourless, dense solution; injection : clear and colorless liquid.

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