Pantoham

Chemical name

R-4-[(2,4-Дигидрокси-3,3-ди��етилбутирил)амино]бу��ират calcium (2:1)

Gross

C20-H36-N2-O10-Ca

Characteristics

The white crystalline powder, odourless. Easily soluble in water. Very little is soluble in alcohol.

Of drugs

Drugs, the properties, zerebroproteguoe, antihypoxia, protivosudorozhnoe, antidizuricescoe. Contains in the GABA and directly interacts with the ГАМК_Б-рецепторно-кан��льным complex. Does anabolic processes in the neuron increases utilization of glucose and oxygen brain. Provides neirometabolicescoe, and the neuroprotective effect neirotroficescoe increases resistance to cerebral hypoxia and toxic substances. Regulate neuronal function and restore lost functions. Mild sedative effect combined with a mild stimulant effect. Provides protivosudorozhnoe effect, reduces anxiety motor. Activates mental and physical fitness. Is normalization Gamkergicaka neirotransmission with chronic alcohol intoxication and the subsequent lifting of ethanol. Is the blood. Is inhibition acetylation reaction novokaina and sulfanilamidov (down inachtiwatia and prolong effect). Oppressing increased puzarnyi reflex and tone detruzora. Malotoksicen not have tertogennogo and embriotoksicski Actia.bystro drawn from the blood, C_max in tissues achieved through 1hr Passes through GEB, the greatest concentrations are in the liver, kidney, in the wall of the stomach and skin. Report from the body within 48 hours unchanged to the : 67.5% dose excreted in kidneys 28.5% return with faeces.

Indications

Violations of the higher brain functions of different genesis of children and adults (treatment and prevention). Adults : in komlexna therapy cerebrovascular insufficiency, senilna dementia (initial shape), резидуально-органиче��кого damage the brain, cerebral organic deficiency in schizophrenia, extrapiramidale giperkinezov structure inherited disease of central nervous system (mioclonus-epilepcia, trochaic Gentington, gepatotserebralnaya dystrophy and parkinsonism), chronic ekstrapiramidnyi neirolepticski syndrome (giperkineticski akineticski and on the corrective and preventative care), the CNS and brain injuries; vertebralnah nervous system lesions in the form of sore syndrome (neck bone, pozvonocna syndrome artery, etc.), neuralgia troinicnogo nerve (in combination with novohammo and finlepsinom), epilepsy, accompanied by a slowdown of mental processes (with protivosudorojnami means); psihoemotsyonalnaya congestion, declining mental and physical efficiency to improve concentration and Zapominaniya.detam : perinatal encephalopathy, mental retardation, mental, speech and motor development, infant cerebral palsy, v (klonica shape), epilepsy (especially polymorphic attacks and small seizures) and epileptiformnye syndromes (in combination with protivosudorojnami means). Adults and children over 2 years : urination disorders different etiology (pollakiuria, peremptory craving, mandatory urine incontinence, enourez).

Pregnancy and lactation

Contraindicated in pregnancy (I term).

Contraindications

Hypersensitivity, acute severe kidney disease, pregnancy (I term).

Side-Effects

Allergic reaction (rhinitis, conjunctivitis, skin rashes).

Patient interaction

Effect increase glizin and ksidifon. Prolong the barbiturates, potenziruet protivosudorozhnykh effects of memory, local anesthetics (novokaina). Prevents side effects of phenobarbital, finlepsina, Neuroleptics.

Precautions

In case of allergic reactions reduce the dose or cancel product.

Dosing and Administration

Inside through 15-30 minutes after eating, in the morning and afternoon hours. Adults : 0,25-1 Mr. welcome feature g / day, treatment of 1-4 months (up to 6 months), a second course through 3-6 Mes.shizofrenia (in combination with neiroleptikami, antidepressants, tranquilizers) : sunbathing g / day, treatment Mes.epilepcia 1-3 (in combination with anticonwulsantami) : 0.75-1 g / day course to one year in prison and a более.Эктрапирамидны�� giperkineza of integrated therapy : on sunbathing g / day, treatment four months and Bolee.posledstvia CNS and craniocerebral injury : 0.25 g 3-4 times a Sutki.dla recovery efficiency at higher loads and Pichinde conditions associated with old age : 0.25 g three times a Sutki.detam : single dose of 0.25 g up to 1 year-0.5-1 g / day, 1 to 3 years, 1.5-2 g / d, 3-15 years 2.5-3 g / d; dose up for 7-12 days, the admission of a maximum dose has 15-40 days, then the dosage is gradually reduced to repeal within 7-8 days; treated 1-3 months with the mandatory break before the next course pantogama or any other memory in a 2-bed Mes.rasstroistva : adults 0.5-1 g 2-3 times a day, the children of 0.25 g daily dose of 25-50 mg / kg treated 1-3 months.

Literature

Pantogram the clinic mental illness childhood (manual for doctors) .- Moscow : Russian Federation, IRI Psychiatry, 2000 .- 28 pp.

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