Pyritinol

Chemical name

3,3'-[Дитиобис(метилен)]��ис[5-гидрокси-6-метил-4- пиридинметанол (and as hydrochloride monohydrate)

Gross

C16-H20-N2-O4-S2

Characteristics

White or white with a slightly yellowish white crystalline powder. Easily soluble in water, very soluble in alcohol.

Of drugs

Drugs, the properties, stimulating metabolism in the central nervous system, improves cerebral blood circulation. Improves metabolic processes in the brain, increases the stability of the brain to hypoxia, and the understanding of glucose metabolism, the exchange of nucleic acids activates holinergicakie processes. Improves penetration glucose and sodium ions through GEB reduces excess education lactic acid facilitates the entry of free fatty acids, amino acids and acetic acid in the brain and liver. 4-3 cell membrane inhibits the activity of lysosomal enzymes and the emergence of free radicals. There is evidence of the ability to reduce the content of GABA in the nervous tissue. And weak stimulant, and antidepressive little sedative Effectom.usilivaet flow and increases the delivery and utilization of oxygen in ishemizirovannah zones of the brain, intensifying the exchange of glucose in the brain sections with postishemicakimi injury. Do alfa-ritm EEG while reducing teta- and delta-ritmov. The methodical implementation enhances mental efficiency, improve memory, learning. Improves flow properties of the blood, increasing the ATF in the erythrocyte membrane and increasing the elasticity of cells and turnover Krovi.pri ingestion absorbed quickly and fully. Time to C_max - 30-60 min. Bioavailability and 85% (76-93%). Linking plasma protein-20-40%. Passes through GEB and other gistogematicalkie barriers, including placental. The brain accumulates predominantly white substance. In the few enters breast milk. Rapidly metabolized in the liver with the formation of the pharmacologically active metabolites. Excreted mainly kidneys in the form of metabolites, 5% shall be provided with faeces. T_1/2 is 2.5 hours Fully extracted through 48h (most of the doses in the first 4 h, about 74% on the first day). Inside the koumouliruet not.

Indications

Block and depressive state (presenilny, senilny, маниакально-депресси��ный psychosis, �ревожно-депрессивный �indrom, erased polymorphic subdepressivee state, and psihoastenopodobne ipohondricescie disorders), psihoorganiceski syndrome, astenicescoe state adinamia, neurozopodobne disorders organic genesis, wegetososudistaya distonia, migraine, traumatic and vascular encephalopathy, cerebral arteriosclerosis, the effects of cerebral circulation, and CNS intoxication neiroleptical therapy (as a reader), dementia (primary degeneratius, vascular and mixed genesis), memory, thinking, nijenie ability to focus, premature onset of fatigue, lack of motivation and incentives, actual violations; children, mental retardation, zerebrastenicescoe disorder, mental retardation, encephalopathy.

Restrictions on the use of

Pregnancy, breast-feeding.

Pregnancy and lactation

Application of pregnancy is possible only by strict testimony in cases where the presumed benefit to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to penitsillaminu), agitation epilepsy, a higher sudorojna preparedness, liver and / or kidney failure, the change picture peripheral blood of diffuse connective tissue, male, vesicular disease.

Side-Effects

From the nervous system and sensory organs : insomnia, anxiety, irritability, agitation (children), headache, dizziness, fatigue, anorexia, the Vkusa.so part of the intestine : nausea, vomiting, diarrhoea, tranzithornoe increasing transaminaz, Holetaz.prochie : artralgia, flat zoster, pemfigoidnye skin reaction, alopecia, allergic reactions (skin rash and mucous shells itch, hyperthermia).

Patient interaction

Increases side-effects penitsillamina, drugs and gold sulfasalazina.

Overdosing

Symptoms : signs of an Zns.lechenie : symptomatic therapy.

Precautions

Do not take piritinol during the evening Casa.sleduet bear in mind that in patients with concomitant Rheumatoid Arthritis and other chronic diseases joints can be undesirable reactions : proteinurija, principally syndrome; Disease; Eozinofilia, thrombocytopenia, lakopenia, agranulozitos, raising antinuclearnah antibodies in the blood; Despnoe, muscle weakness, paresthesia, polimiozit, hepatitis, gematuria, the emergence in the blood Le-kletok.

Dosing and Administration

Inside through 15-30 minutes after eating, the last admission no later than 1730 Adults : on 0.1-0.3 g 2-3 times a day, 0.2-0.6 g / sut. The course of treatment is 1-3 months, in some cases, 6-8 months, the re-training through 1-6 months. In migraines : prevention, to 0.3 grams per day for a period of two to three days before the anticipated attack mild attack - 0.2 g Odnocratno.detam : 1-3 years 0.05-0.1 g / d, 4-10 years 0.1-015 g / day, 11-14 years, 0.2-0.3 g / day 2-3 reception. The course of treatment, from two weeks to three months, the re-training through 3-6 months.

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