Vinpotropil

Roman name

Vinpotropile

Characteristics

Combined preparation containing церебровазодилатирую щее (vinpocetin) and properties (piracetam) funds.

Pharmacokinetics

Vinpocetin well absorbed. Bioavailability is about 50-70%. C_max achieved through one hour after administration. Therapeutic concentrations in the plasma of 10 to 20 ng / J T_1/2 4.8 C.pirazetam after taking into well absorbed and penetrates to the various organs and tissues. Bioavailability is about 95%. C_max achieved through 0.5-1 h after administration inwards. Penetrates through гемато-энцефалически�� barrier accumulates in brain tissue from 1-4 h after administration. The cerebrospinal fluid appears much more slowly than in other tissues. There is biotransformation and 2 / 3 is aired, unedited, within 30 hours T_1/2 of plasma - 4,5 p, of the brain - 7.7 hours

Farmakodinamika

As церебровазодилатирую щее tool improves cerebral blood circulation, a slight decrease AD Systems, the expansion of cerebrovascular, increasing blood flow and improving the supply of the brain with oxygen and glucose; increases resistance brain cells to hypoxia, facilitating transport oxygen (as a result of reduced affinity cells thereto) and energy substrates to the fabric, increasing the absorption and metabolism of glucose and metabolism switching energy in a better direction RTL; to the accumulation in the tissues and Zamf ATF (Braking fosfodiesterzy and adenilatziklazy), the rest of the brain tissue; vazodilatirtee effect due to the direct action of Bath in the smooth muscles receptacles are brain it is the phenomenon of "victimize", and increases blood ishemizirovanna the brain without altering the blood intact areas; improves microcirculation in the brain by reducing the aggregation of platelets, lowering blood viscosity, increasing seats Eritrotsitov.kak properties is having a positive impact on the metabolic processes brain, increases the concentration of enzyme in the brain tissue, increased synthesis of RNA and phospholipids, stimulates glikoliticaskie processes enhances glucose disposal; integrativuyu improves the brain contributes to the consolidation of memory facilitates the process of learning; the speed of the institution in the brain, improves, with no sosudorasshiratego actions ingibiruet agregatia activated platelets; is a protective effect with damage brain caused gipoksiei, poisoning, electric shocks; increases alpha and beta reduces delta-aguosti engjefalogramme to lessen the severity nystagmic vestibular; improves communication between hemispheres brain and sinapticescuu conductivity in neokorticalnah structures improves mental activity enhances brain blood; no sedative, psihostimulirutm influence. Effect develops gradually.

Indications

Lack of cerebral circulation (recovery period ishemicski and haemorrhagic stroke, encephalopathy different genesis); Vascular parkinsonism genesis, intoxication, injury to the brain and other central nervous system diseases accompanied by the decline интеллектуально-мнес��ических functions; psihoorganiceski syndrome dominated signs and losing adinamii, asteniceski syndrome; labirintopatia, Ménière syndrome; migraine prevention and kinetozov.

Contraindications

Hypersensitivity, pregnancy, lactation period expressed by the disruptions of heart disease (the plight), the acute phase of haemorrhagic stroke, kidney and / or liver failure, the age to 14 years.

Side-Effects

In rare cases : mental and dwigatelnoe arousal, irritability, imbalance, reduced ability to concentrate, anxiety, insomnia, gastralgia, nausea, vomiting, constipation or diarrhoea, reduced appetite; Dizziness, headache, ekstrapiramidnye violations increased sexual activity, the deterioration of the current stroke, tachycardia, arrythmia, deceleration предсердно-желудочко��ой conductance.

Patient interaction

It increases the risk of bleeding complications in the face of geparinoterapii; Enhances effects of hormones the thyroid gland, antipsihoticeskih funds (doses), the proximity anticoagulants, psihostimulatorov; Weakened the effect protivosudorozhnykh preparations (reduces sudorozhny threshold).

Storage conditions

List B. In a dry, the dark place at a temperature of no higher than 25 ° C

Shelf life

The registration

002632/01-2003

The drug forms

Capsule yellow cap with the red; Content capsules, powdered white, or almost white.

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