Depakin

Roman name

Depakine

The composition and the form of

Syrup for children 5.7% - 100 mlvalproat sodium 5.7 gwo bottle 150 ml; In a box one bottle complete with drugs Lozhkoy.poroshok liofilizirovanny for solution for injection-1 amp.valproat sodium-400 megawatts sealed to 4 ml together with the solvent in 182,000,000; in the box four Complekta.tabletki Film-coated, soluble in the gut-1 tabl.valproat sodium-300 megawatts blistere 10 pcs. ; in a box 10 blisters.

Pharmacokinetics

Quickly and completely absorbed from the gastrointestinal (eating does not alter the absorption). Bioavailability about 100%. C_max achieved in 2 hours, equilibrium concentration in the age day. Linking blood plasma 90%, decreasing with increasing doses. Easily passes gistogematicalkie barriers, including GEB. Treated biotransformation in the liver (oxidized and kongugiruet with glukuronova acid). Report mostly in the urine; T_1/2 is 15-17 hrs (against induction biotransformation enzymes reduced to 6-10 hours).

Farmakodinamika

Противоэпилептически й mean a wide spectrum of activity. And trankvilizirutmi properties, reduces fear, improves psihoemotsyonalnoe state.

Clinical pharmacology

Vsokoeffectiven in absansah and visochnykh psevdoabsansah, with little emotional pripadkah.

Indications

Epilepsy (all forms), conduct disorder associated with epilepsy syndrome sudorozhny with organic diseases of CNS, febrile convulsions and brain practice in children.

Pregnancy and lactation

Contraindicated in the first trimester. In II and III trimestrah use only in extreme cases where the presumed benefit to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь valproatu the sodium of the liver and / or the pancreas, hepatitis, including in the family history, bloody diates, porphyria.

Patient interaction

Do effects, including side, the other противоэпилептически х drugs, barbiturates, Neuroleptics tranquilizers, antidepressants and alcohol. Increases gepatotoksicnosti phenobarbital, difenina, carbamazepina, klonazepama. Simultaneous reception tricyclic antidepressants (imipramin) or difenina may cause Generalized epileptic seizures, klonazepama - absans. Incompatible with salicilatami and varfarinom. Difenin, phenobarbital and carbamazepine reduce concentration in plasma (inducyruut mikrosomaiona liver enzymes).

Precautions

Be wary designate children, especially up to three years of age (the highest risk of hepatotoxicity), and women of childbearing age (obligatory reliable contraception). The treatment requires careful monitoring of liver function (level transaminaz, cium), pancreas, the blood clotting. The surgery, conducted at the time of treatment, a common blood test (including the number of platelets), koagulogramma, timing haemorrhage. During treatment should be deleted reception alcohol.

Storage conditions

List B. In safe from direct sunlight place at a temperature below 25 ° C

Shelf life

3 years

The registration

012595/01-2001

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