Carbasan retard

Roman name

Carbasan # retard

The composition and the form of

1 tablet contains retard carbamazepina 400 mg; blistere in 10 pcs. , in box 5 blisters.

Of drugs

Protivosudorozhnoe, analgezirutee. Does ^ Na + channels membranes of nerve cells, reduces release incident neiromediatornah amino acid increases the brake, interacts with the central adenozinovmi receptor.

Indications

Epilepsy (large and small seizures, mixed form collective epilepsy); Nevralgia troinicnogo nerve (essencialnaya and spread EMG), essencialnaya glossofaringealnaya nevralgia, nesharnyi diabetes, the withdrawal syndrome in alcoholism.

Pregnancy and lactation

Not recommended.

Contraindications

Hypersensitivity, предсердно-желудочко��ая blockade; heart disorders, liver, kidneys, the exchange of sodium. glaucoma, prostate, diseases of bone marrow, acute intermittirutaya porphyria.

Side-Effects

From the central nervous system : dizziness, headache, fatigue, weakness, drowsiness, of walking, balance, coordination of movements, muscle automatic reduction, depression, aggressiveness, the mental processes, hallucinations, noise in the ears, the speech, a sense of discomfort, muscle weakness, peripheral neuritis, pareza, changing taste, activation of latent psychoses; In the elderly, sputannosti consciousness ajitation, diskinesia facial muscles Horeoatetoz.so the musculoskeletal system : artralgia, mialgia, muscle Spazma.so the Skin : urticaria, itching, peeling, exfoliativei dermatitis, eritrodermia, Laiella syndrome, fotochuvstvenosti, syndrome Stevens-Johnson, mnogoformnaya, ekssoudatus or uzlovataya erythema, skin haemorrhages diskoidnaya red erythematosus, exantema, skin vasculita, increased sweating, loss of Volos.so blood : leucocytosis, eozinofilia, lakopenia, Trombozitopenia.so part of the intestine : loss of appetite, dry mouth, nausea, vomiting, diarrhea / constipation, pain in the abdomen, disease, gingivit, glossit, increase in liver enzymes, jaundice; holetsaticeski hepatitis.

Specific guidance

The monitoring cell of peripheral blood and liver enzymes prior to the weekly during the first month of treatment, followed by monthly. After six months of treatment is 2-4 studies per year. Patients suffering from glaucoma, it is necessary to measure the inner pressure.

Patient interaction

Incompatible with MAO inhibitors, furazolidonom. Ters or neutralizes the effect of drugs metaboliziruthan pechenocnami enzyme (mikrosomaiona produces enzymes), miorelaksantov. The joint appointment should be adjusted dose klobazama, klonazepama, etosximida, primidona, valproeva acid alprazolama, Corticosteroids, cyclosporine, digoxin, felodipina, Neuroleptics, imipramina, methadone, theofillina, anticoagulants (drugs, dikumarol), hormonal contraceptives. Changes fenitoina concentration in the plasma. Dioretiki potenziruut giponatriemia caused carbamazepinom. Do gepatotoksicnosti tests. Concentration in plasma reduce phenobarbital, phenytoin, primidon, clonazepam, valproeva acid theofillin tetracycline. Valproeva acid and primidon increase in the concentration of serum active-metabolita карбамазепина-10,11-эпо��сида. Plasma levels increased in the face of antibiotics macrolides, polymer, calcium antagonists, azetazolamida, dekstropropoksifena, propoksifena, viloxazina, danazola, nikotinamida, zimetidina, decipramina. Neiroleptiki and preparations lithium or metoclopramide fostering neurotoxicity.

Precautions

If a severe allergic reactions require immediate removal.

Dosing and Administration

The inside is not liquid, during or after delivery, squeezed small amounts of liquids, 200 mg 1-2 times a day. Optimal dose-800-1200 mg a day. Children 1-5 years of the initial dose of 100 mg / day supporting dose-200 mg 1-2 times a day; 6-10 years initial dose-200 mg / day (reception 1-2), which supports the dose of 200 mg three times a day; 11-15 years of the initial dose of 100 mg twice a day, supporting dose-400 mg three times a day.

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