Lithium carbonate

Characteristics

White granular powder, odourless. Slightly soluble in water, virtually nerastvorim in alcohol.

Of drugs

The drugs-normotimicescoe, antipsihoticescoe, sedative. Does sodium channels in neuron and muscle cells, a shift intraneironalnogo metabolism катехоламинов.Достат��чно fully absorbed in the digestive tract time to C_max is 6-12 hours; T_1/2 increased from 1.3 days after the first dose to 2.4 days after one year of regular admission.

Indications

Maniacal phase of bipolar psychosis, prevention of exacerbations маниакально-депресси��ного psychosis, aggressiveness in psihopatiah and chronic alcoholism, addiction to psychotropic drugs, sexual deviation, Ménière syndrome, migraines.

Contraindications

Hypersensitivity, severe kidney disease and / or liver, severe heart disease, pregnancy, breast-feeding (to the end of breast-feeding).

Side-Effects

Diarrhoea, nausea, vomiting, dry mouth, moderate poliuria, kidney dysfunction, the heart rhythm, braking gemopoaiza, of the thyroid gland, weak tremor hands, drowsiness, alopecia, acne.

Patient interaction

Together with the appointment neiroleptikami and antidepressants on their body mass index, with antipiretikami and slabitionami increase fluid loss and reduced endurance. Not recommended combined with dioretikami because declining kanaltsevaya reabsorbece sodium and risks giponatriemii. NPVS slow excretion of lithium.

Overdosing

Symptoms : the speech, giperreflexia, meals and epileptic convulsions, oliguria, loss of consciousness, collapse, Koma.lechenie : symptomatic.

Precautions

Missing doses had not recovered. It gradually abolish treatment by increasing the spacing between the media, and the steep drop doses. They could not take in water balance (bessoleva diet, the lack of sodium, diarrhea, vomit). Before treatment should be identified Cl creatinine (to be no more than 0.17 mL / s) and the amount of residual nitrogen, a Ekg-analysis and general blood analysis to the definition Monday, and then regularly at least once a month to monitor the level of lithium in the blood within 12 hours after taking the last dose.

Dosing and Administration

Inside, at the time of delivery, squeezed water or milk. Adults appointed dose, regular admission which is the equilibrium concentration in the blood within 0.6-1.0 mmol / l for more than six months for a preventive actions; The dose of 1 g / day of stabilizing the concentration in 10 to 14 days. Even with the improvement reflected should not interrupt treatment, in order to avoid recurrence. Children lithium concentration in the blood shall be within 0.5-1.0 mmol / O

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