Lithium oxybate

Chemical name

Lithium gamma-okshibutirat

Gross

C4-H7-O3-Li

Characteristics

White or white with kremovatam white crystalline powder. Easily soluble in water, it is difficult to alcohol, pH 20% aqueous 8,5-9,5.

Of drugs

Drugs, the sedative, normotimicescoe. Ion lithium is the antagonist of sodium and / or calcium-Gamk-anion mediator of the central braking activates glucose utilization and energy the brain, respiratory activity and blood Tkanei.liti rapidly and completely absorbed out of a / m depot, C_max achieved through sunbathing and The blood is not associated with the protein. Distributed mainly aqueous phase organism, but also spreading to bone tissue, and schitovidnuu iron and the brain. 2176 in the tissue is slow and requires 6-10 hours Write mainly with urine, T_1/2 - 20-24 h. Equilibrium concentration in the serum obtained after one week.

Indications

Gipomaniakale and maniakale of moderate, Psychopathy and neuroses, organic and other disease with relapses affectivei disorders, asthma prevention and affective psychoses shizoaffectiveh (маниакально-депресси вный psychosis, schizophrenia with the periodic and �риступообразно-прогр едиентным Over etc.).

Contraindications

Hypersensitivity, severe kidney disease, gastrointestinal (under increasing), the circulatory system (circulatory disorders, adults), expressed metabolic and endocrine disorders, cataract.

Side-Effects

Early treatment : diarrhoea and dizuriceskie phenomenon, the general malaise, dizziness, drowsiness, muscle weakness, tremor (hands). In the later stages of therapy : flatulence, burp, nausea, vomiting, diarrhoea, adults, tremor and policies, the development of diffuse netoksicski goitre allergic reaction (itching).

Dosing and Administration

V / m. Non-dose 0.5-1 g daily, until 3 in the city of preventive treatment to begin with a dose of 0.5 g.

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