Valproic acid

Chemical name

2-propilvalerianova acid (and the form of limestone, magnieva or sodium salt)

Gross

C8-H16-O2

Characteristics

White melkochristalliceski powder. Easily soluble in water and alcohol.

Of drugs

The drugs-protevoepilepticescoe, miorelaksirutee, sedative. Ingibiruya Gamk-transferzu increases in the central nervous system gamma-aminomaslana acid, which has been shown to slow the threshold anxiety and the level of preparedness sudorojna motor of the brain. The ingestion dissociation to valproat-iona who absorbed in the blood plasma. Food reduces the removals. C_max plasma determined through 1-4 hours Therapeutic concentration in the blood is 50 to 100 µ g / ml (can be much higher or lower depending on the permeability of GEB from the patient). About 90% is in the blood plasma proteins. Metabolised in the liver : most glukuronidiruetsa, smaller battery involving either mikrosomaionah enzymes or muthondriah hepatocytes (beta-okislenie). T_1/2 ranged from 6 to 16 hours, depending mainly on mikrosomaionah activity of liver enzymes. Metabolites and compared allocated memory. A few valproeva acid is milk.

Indications

Various forms of Generalized seizures : small (absansa), large (apnoea) and the polymorphic; Used in the focal pripadkah, child tick.

Restrictions on the use of

Children's age (simultaneous designation of several protivosudorozhnykh funds), aplasia bone marrow, pregnancy (postponed).

Contraindications

Hypersensitivity, incl. "family" (the death of close relatives in the face of the reception valproeva acid), diseases of the liver and pancreas (on the part of patients to a significant decrease metabolism in the liver), bloody diates, pregnancy (I term), nursing (nursing mothers should stop breast-feeding).

Side-Effects

Nausea, vomiting, diarrhoea, stomach, anorexia or increased appetite, abnormalities in the liver, drowsiness, tremor, parestesia, sputannosti consciousness, peripheral edema, hemorrhage, lakopenia, B19. The long-admission temporary hair loss.

Patient interaction

The effect of increasing anti etc., sedatives and narcotic drugs. Diarrhoeal disorders often develop in the face of spazmolitikov and coating means. Alcohol and other gepatotoksicnae the better the chance of liver damage, combined or acetylsalicylic acid, the risk of bleeding.

Dosing and Administration

Inside, during or immediately after eating. Daily dose for adults at the beginning of treatment is 0.3-0.6 g, within 1-2 weeks of gradually increase to 0,9-1,5 g single dose for adults, and 0,3-0,45 Daily dose for children 15-50 mg / kg (in the early-15 mg / kg, followed by a gradual increase of 5 to 10 mg / kg per week).

Directory → Neurotropic funds → Normotimiki → Valproic acid