Sulbutiamine

Chemical name

N,N'-[Дитиобис[1-метил-2-[- (2-метил-1-оксопропокси )этил]-2,1-этенедиил]]би��[N-[(4-амино-2-метил-5-пир имидинил)метил]формам ид]

Gross

C32-H46-N8-O6-S2

Characteristics

Synthetic compound close to the building tiaminu (is open tiazolny cycle additional disulfidnuu communications and lipofilny ether), well rastvorimo in fats.

Of drugs

The drugs-stimulating metabolism in the central nervous system, antiastenicescoe. Regulates metabolic processes in the central nervous system. Accumulating in the cells retikuliarna formation gippocampe and serratus izviline, Purkinje cells and clubockah granular layer crust holding (according to the иммунофлюоресцентног о histology study). In плацебо-контролируем��х clinical trials using psychometric tests and the rating scale shown high efficiency in the treatment of symptomatic functional Pichinde Sostojani.bystro drawn from the blood, C_max achieved in 1-2 h after administration. Easily passes through GEB; Ability to enter breast milk is not known. T_1/2-about 5 hours Report Pockami.v experiments on animals show that tertogennogo action. According to the results of clinical trials, will not affect the development of a fetus, but sufficient clinical data are not available.

Indications

Astenicescoe of the hypothetical and avitaminozah, lengthy illnesses after surgical intervention.

Restrictions on the use of

Pregnancy, breast-feeding.

Pregnancy and lactation

Not recommended during pregnancy (not enough clinical experience) and during breastfeeding (no data on the penetration of breast milk).

Contraindications

Hypersensitivity, the children's age.

Side-Effects

Allergic reactions initiated (for the elderly).

Specific guidance

No impact on the ability to focus attention and psychomotor speed reactions.

Overdosing

Symptoms : agitated (euphoria tremor limbs). Treatment : overdose symptoms are quickly and do not require special treatment.

Dosing and Administration

Inside, 400-600 mg / day, the duration of the case.

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