Buprenorphine

Chemical name

[5альфа,7альфа(S)]-17-(Цик��опропилметил)-альфа-(1 ,1-диметилэтил)-4,5-эпок��и-18,19-дигидро-3-гидрок��и-6-метокси-альфа-мети л-6,14-этенморфинан-7-ме��анол (as hydrochloride)

Gross

C29-H41-N-O4

Characteristics

The white crystalline powder. It is soluble in water, soluble in alcohol.

Of drugs

The drugs-analgezirutee (drug). Is partial agonist opioid receptor subtype mu- and kappa-retseptorov antagonist. To a lesser degree than morphine, it is addictive and therapeutic Zawisimosti.pri sublingwalna software C_max plasma is an average of 1 h. T_1/2 with in / m and sublingual application, 3-6 pm Evenly distributed over the fabric, cut through GEB. Metabolised in the liver metabolism products made with jelchew, few excreted kidneys.

Indications

Pain syndrome high intensity (after surgeries, and in cancer patients with myocardial infarct, renal kolica, burns).

Restrictions on the use of

Snorkel and renal and hepatic failure, a fractured skull, pregnancy, breast-feeding (nursing mothers should stop breast-feeding).

Contraindications

Hypersensitivity, physical dependence.

Side-Effects

Headache, dizziness, sweating, dry mouth, nausea, vomiting.

Patient interaction

Do (mutually) and the side effects and toxicity of MAO inhibitors and means oppressive central nervous system (tranquilizers, doses, etc.).

Overdosing

There oppression breathing Centra.lechenie : give naloxone, as well as symptomatic funds.

Dosing and Administration

Inside, in / in, in / m subilgvalno. Under dose for adults with the in / in and / m introduction-0,15-0,3 mg / kg If necessary, repeat injections every 3-4 C.razova dose for a child is 0.25 mg / kg, the maximum daily 2 mg / Kg.pri sublingual admission to 250400 equivalent to the interval between admission 6-8 pm

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