Butorphanol

Chemical name

17-(Циклобутилметил)мо��финан-3,14-диол (and in the form of tartrate)

Gross

C21-H29-N-O2

Characteristics

The white crystalline powder, soluble in water.

Of drugs

The drugs-analgezirutee (drug). And агонист-антагонистич��скими properties of the opioid receptors : stimulates kappa- and blocks �ю-рецепторы.Абсорбир��ется in the system in the bloodstream in / m introduction in 10-15 minutes, with the nasal mucous membrane, through 15 min. Linking blood plasma 80%. Passes gistogematicalkie barriers, including GEB and placental. Metabolised in the liver. Return (mostly in the form of metabolites) in the urine (70-80%) and faeces (15%); , Unedited, with the urine is only 5%. Secretiruetsa lactoiruta mammary gland, the concentration in breast milk of mothers receiving product in / m in the dose of 2 mg four times daily, is 4 µ g / O T_1/2 young patients is 4.7 hours, the older-6.6 h, in patients with acute disabilities kidney 10.5 C.stimuliruet emetic center, a narrowing of inhibition enhances system AD pressure in the pulmonary artery конечно-диастолическ��е pressure from the left and jeludocke round. Light affects the smooth musculature ulcers; Not stupid diurez not spazmiruet sfinkter Oddi.posle in / in the place is immediately, the / m for a period of 10 minutes. Maximum analgeziruty effect develops in a few minutes after the in / and in 30 to 60 minutes after the on / m introduction maintained for a period of 3-4 hours

Indications

Pain syndrome of moderate to severe symptoms of different etiology : posleoperazionny, childbirth, etc., migraine, premedikation and balanced anaesthesia.

Contraindications

Hypersensitivity, pregnancy (with the exception of controlling pain in childbirth), breastfeeding.

Side-Effects

Drowsiness, dizziness, nausea and vomiting, headaches, a feeling of warmth, tachycardia, dry mouth, gastralgia, anxiety sputannosti consciousness, euphoria, nervousness, parestesia violation Conclusion lability AD violation urination, addictive, drug dependency, allergic reactions (urticaria, skin).

Patient interaction

Do (each) a dampening effect on the central nervous system of alcohol, barbiturates, tranquilizers, antigistaminnah drugs.

Overdosing

Symptoms : giperventilatia, coma, cardiac and / or vascular Nedostaternsti.lechenie : need continuous monitoring, maintaining pulmonary ventilation system hemodynamics, body temperature; IVL (in the coma). A specific antagonist naloxone is.

Precautions

Be wary appointed in the run-up to maternity leave, with head injuries, respiratory oppression, emotional volatility, patients with drug addiction in history, and human liver, kidneys and the cardiovascular system, the elderly, work with the instruments and driving vehicles.

Dosing and Administration

Doses are individually. For heavily controlling pain in / in or / m high doses, 1 and 2 mg (respectively) one, if necessary (depending on the intensity of pain) for 0.5-2 mg in / in or 1-4 mg in / m every 3-4 C.do operations-2 mg in / on for 60-90 minutes, at the time of the operation, 0.5-1 mg in / in a few Wvedeni.u women on 1-2 mg in / in or / m, if necessary 1x, repeated at 4 pm

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