Nalbuphine

Chemical name

(5альфа,6альфа)-17-(Цикло бутилметил)-4,5-эпоксим орфинан-3,6,14-триол

Gross

C21-H27-N-O4

Of drugs

The drugs-analgezirutee (drug). And properties agonista-antagonista opioid receptors. Oppressing CNS has analgezirutee, nursing, protivokashlevoe effect. Mu-retseptora institute and blocks каппа-рецепторы.Хорош о absorbed by any means injecting : takes effect after 2-3 min after in / in and after 15 minutes when s / c or / m injection. In appointing the interior of four to five times less active than those in the / m software. C_max after the muscle is a 0.5-1 hours T_1/2 is 3-6 hours The liver is biotransformation, metabolites are with jelchew in intestine and then with faeces removed from the body. The urine excreted in minor amounts.

Indications

Pain syndrome, and the average intensity of the concerns with myocardial infarct, in preparation for the operation (prevention), and aftercare period; As a further means of analgesics in general anesthesia.

Restrictions on the use of

Violation of the liver and kidneys, increased intracranial pressure, respiratory depression (also for uremia, acute bronchial asthma, severe infections), operational intervention hepatobiliar system (possible causes tumours Oddi), pregnancy, childbirth, children and youth age (up to 18 years).

Contraindications

Гиперчувствительност ь.

Side-Effects

From the central nervous system : drowsiness, and the oppression of breath (small dose urejaut and increase the depth of breathing movements), headache, euphoria or depression, suffering, Galloucination.so the circulatory system : hypertension / gipotenzia, aetiology / tachycardia, swelling Legkih.so the stomach : dry mouth, nausea, vomiting, neuralgia, spasticskie Boli.allergicakie reactions : anaphylactic or anaphylactoidnyi shock bronhospazm, urticaria, throat swelling, itching, Chihanie.prochie : sweating, pain in the ground / m injection.

Specific guidance

The finished drug form as a preservative disulfit sodium, which can cause in patients with bronchial asthma (with the high degree of sensitivity to sulfitu) attacks suffocation or anaphylactic shock anaphylactoidnyi.

Patient interaction

General anaesthetics, tranquilizers, sedatives and hypnotics funds increased alcohol effect, incl. side (with combination therapy to reduce the dose nalbufina and / or these drugs).

Overdosing

Symptoms : increased side effects, loss of consciousness, coma, periodic breathing type Chein-Stokes, lips and lowering the temperature of skin, lowering body temperature, unconsciousness; Death (paralysis of respiratory centre). Treatment : washing stomach, in / in a specific antidotes - naloxone or nalorfina, rooms, maintaining vital functions.

Precautions

Not recommended for use more than three days and more than dosing because possible physical dependence. The sudden end to the reception after long-term use can cause withdrawal syndrome (spasticskie pain in the abdomen, nausea, vomiting, rinorea, slezotechenie, weakness, anxiety, increased body temperature). Be wary appointed to emotional instability, drug abuse (high probability of acute asthma symptoms). The sedative and hypnotic effects should not be applied to drivers out of vehicles and people, a profession which requires quick mental and motor reaction.

Dosing and Administration

In / in, in / m. Adults : in / in or / m 0,15-0,3 mg / kg body weight. If necessary, repeat every 3-6 hours The maximum single dose of 0.3 mg / kg, the maximum daily 2.4 mg / Kg.detam : in / in or / m 0.1-0.25 mg / kg The maximum single dose of 0.25 mg / kg with a maximum daily 2 mg / Kg.pri general anesthesia : originally introduced in / drip in the 0,3-3,0 mg / kg for 10-15 minutes, then supporting dose 0.25 mg / kg once.

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