Naloxone

Chemical name

(5альфа)-4,5-Эпокси-3,14-ди гидрокси-17-(2-пропенил) морфинан-6-он (as hydrochloride)

Gross

C19-H21-N-O4

Characteristics

White or almost white powder, soluble in water, the diluted acid and concentrated scheloch, poorly soluble in alcohol, virtually nerastvorim broadcast and chloroform.

Of drugs

Drugs, the blocking Waismann receptors. Warn or dosage caused by agonists, respiratory depression, and central nervous system, tissues, as well as disforiceski and psychotic effects агонистов-антагонист��в. Analgeziruta activity is not, it is euphoria, respiratory depression, obstipatia. It is not tolerance, and drug dependency. The drug provokes withdrawal syndrome. T_1/2 is 30-80 min. Metabolised in the liver. Return with urine. Following the introduction of the effect develops in 2 minutes and lasts 30-240 minutes (depending on the dose and the method of introduction).

Indications

Treatment and diagnosis of acute poisoning drug analgetikami and hypotension in septicescom shocked.

Restrictions on the use of

Organic heart disease, drug dependency to narcotic analgesics, pregnancy, breast-feeding (should stop breastfeeding), children's age.

Contraindications

Гиперчувствительност ь.

Side-Effects

Nausea, vomiting, tachycardia, hypertension, tremor, the cardiac conductance.

Patient interaction

Significantly reduces or eliminates the effects of narcotic analgesics (agonists or агонистов-антагонист��в).

Dosing and Administration

B / introduced in 0,4-2 mg product, in the absence of economies of repeat injections at intervals of 2-3 minutes. If a separate life is not to be refunded after 10 mg substance, the diagnosis of drug poisoning analgetikami as the cause respiratory supression, questioned.

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