Pentazocine

Chemical name

(2альфа,6альфа,11R*)-1,2,3,4,5 ,6-Гексагидро-6,11-димет��л-3-(3-метил-2-бутенил)-2, 6-метано-3-бензазоцин-8- ол (as hydrochloride or lactate)

Gross

C19-H27-N-O

Characteristics

The white crystalline powder, soluble in aqueous solutions of acids.

Of drugs

The drugs-analgezirutee (drug). Interfaces with opiatnami receptor located in many CNS divisions, including bark brain limbicescuu system Diencephalon, dystonia, and in peripheral tissues, causing activation antinozizeptivna system and the changing socio-emotional pain. At the same time, to displace morphine from the opiatnami receptors, causing the withdrawal syndrome in persons with the physical addiction to narcotic analgesics. Other effects of the drug : Activation vomitoxin centre, respiratory depression, obstipeerootee act aetiology, the decline AD and failure is also linked to the impact on Waismann Retseptora.horosho rats after oral, in / m and m / to the introduction. Connectivity plasma protein is 50-60%. Treated biotransformation in the liver with the formation of active metabolites. T_1/2 - 2-3 pm Excreted kidneys, 5-13% return in an unmodified form. The effect and the maximum severity are, respectively, in 2-3 min and 15-30 min after in / with the introduction; 15-30 min and 30-60 min after in / m and enteralnogo introduction. Duration of up to 3 hours

Indications

Expressed pain syndrome, myocardial infarction.

Restrictions on the use of

Pregnancy, breast feeding, carefully use in children up to 2 years.

Contraindications

Hypersensitivity, respiratory distress, bronchial asthma, brain damage, organic brain damage, epilepsy, jelchnokamennaya disease anesthetic disease, renal and hepatic failure.

Side-Effects

Adjust, drug dependence syndrome "lifting", respiratory depression, bronhospazm, nausea, vomiting, constipation, atony bladder, drug abuse, adults, fluctuations AD allergic reactions.

Patient interaction

Do effects doses tranquilizers, sleeping, alcohol. Naloxone and naltrexone are specific antagonists preparation.

Dosing and Administration

Inside, adults 50 mg three times a day before meals, if necessary licenses dose increase to 100 mg; Maximum daily intake inside-350 Mg.p / to the in / m, adults, 30-45 mg, if necessary, the re-introduction of a 3-4 hour children from 1 to 6 years at the rate of 1 mg / kg in Sutki.v / in, adults 30 mg, if necessary, the re-introduction of 2-3 hrs, children no more than 0.5 mg / kg per day.

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