Piritramide

Chemical name

1'-(3-Циано-3,3-дифенилпр��пил)-[1,4'-бипиперидин]-4 '-карбоксамид

Gross

C27-H34-N4-O

Of drugs

The drugs-analgezirutee (drug). Activates mu-opiatnye receptors in the spinal cord and notsytseptiveh centres cheeks, and the cortex. Increases pain threshold sensitivity and improves the portability pain. A fast : analgesia occurs in 1-2 minutes after the on / in the beginning and after 20 minutes, with the s / c or / m applique, a 4-6 hours After a single on / m of C_max achieved through 15 minutes biotransformiroetsa in the liver and out of the organism, with T_1/2 - 4-10 hours Application together with the other neirotropnami means, tranquilizers, diprazinom (pipolfenom), etc. provides balanced analgesia (ataralgeziu), including : anesthesia for childbirth. Combining with neiroleptikami - droperidolom (inwards to 1.25 mg twice a day) or galoperidolom (inwards to 0.5-1 mg / day), also reinforces analgeziruty effect, eliminates nausea and vomiting, had a positive impact on their mental state.

Indications

Intensive pain syndrome, including after surgical interventions, and in malignant tumors.

Contraindications

Hypersensitivity, severe depletion, coma, respiratory depression, intracranial hypertension, aged age.

Side-Effects

Physical and mental dependence, tolerance cravings (violation of coordination, tremor, anxiety, increased AD), sedation, drowsiness, nausea, vomiting, diarrhoea or constipation, respiratory depression, hypotension, aetiology, the acute porphyria, and increased vitality sfinkterov psoriasis ways ERCP pancreas, bladder, skin, skin.

Patient interaction

Incompatible with MAO inhibitors (can develop paroxizmalnaya CNS stimulation and arterial hypertension). Barbiturates, benzodiazepines, derivatives fenotiazina gaseous substances general anaesthetics and sleep means potenziruut respiratory depression.

Overdosing

Symptoms : failure, oppression and stops breathing, hypotension, tachycardia, dizziness, the consciousness Koma.lechenie : introduction antagonists, naloxone (again in the low-dose in adults 0.4 mg every 2-3 minutes if necessary); Intensive therapy, including intubatia, IVL, gipertermiu, maintenance BCC; Atoniu bowel corrigiruut cholinesterase inhibitors, or парасимпатомиметичес кими means.

Precautions

Be wary designate of pregnancy and breastfeeding, gipotireoze, the lack of breathing, kidneys, liver and crust napochechnikov, hyper prostate gland in old age, and shock conditions, the combination of the agricultural chemical. MAO inhibitors should be revoked for 10 or more days prior to the treatment. During outpatient treatment is not recommended driving a car or work with potentially dangerous machinery.

Dosing and Administration

V / m, n / a, adults Seven mg or 1-2 ml of 0.75% solution; If necessary, again in a couple of hours, to a lesser Doze.v / in the slow (for a rapid effect) :-adults 15-20 mg, children 0.05-0.1 mg / kg The doses are supporting in the case of very severe pain (such as malignancies) allowed increases and the introduction of every 6-8 hours

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