Трамадол-словакофарм��

Roman name

Tramadol-Slovakofarma

The composition and the form of

1 capsule contains tramadol hydrochloride 50 mg; blistere in 10 pcs. , in box 1 or 2 blister.1 suppository rektalny-100 mg; in blistere 5 pcs. , in box 1 blister.1 ml solution for injection 50 mg; USD in 1 and 2 ml, in a Box 5, 10 or 100 st.1 ml for admission into 100 mg; in the glass flakonah-kapelnytsah to 10 ml, in the box one bottle.

Of drugs

Analgezirutee. Mu- institute, and delta- kappa-opioidnye receptors. Suppress reverse takeover norarenalina and serotonin neurotransmission in the central nervous system.

Pharmacokinetics

Once inside absorbed more than 90%. Absolute bioavailability was 68% (oral) 70% (rektalno). C_max recorded in 2 hours Associated with the blood supply by 20%. Easily passes GEB and placental barrier. T_1/2 in the second phase-6 pm Kidney excreted unchanged in the form of (30%) and in the form of metabolites (60%). About 0.1% rate imposed by another mother's milk.

Clinical pharmacology

The effect develops in 10-15 min.

Indications

Pain syndrome : posleoperazionny period injury, myocardial infarction, nevralgia, cancer. The painful diagnostic or therapeutic intervention.

Pregnancy and lactation

Only with absolute testimony.

Contraindications

Гиперчувствительност ь (including the brain), the acute intoxication of alcohol, drugs, analgetikami or other psychotropic drugs, the withdrawal syndrome; adolescence (before age 14), capsules, suppositories, injection, chest age (up to 1 year), solution for the reception inside.

Side-Effects

Dizziness, fatigue, block, drowsiness, fatigue, convulsions, tremor, hallucinations, sweating, dry mouth, nausea, vomiting, constipation, itching, neuralgia; Rarely palpitation, tachycardia, ortostatical gipotenzia.

Patient interaction

Do (mutually) effect of tranquilizers, sleeping, alcohol and neprognoziruemo, MAO inhibitors.

Overdosing

Treatment : An Introduction naloxone (specific antagonist); Maintain adequate pulmonary ventilation and symptomatic therapy (with a specialist).

Precautions

The combined with MAO inhibitors. It should be borne in mind that can change the reaction rate (ability to drive and the various mechanisms).

Dosing and Administration

Inside, c / a, in / m, / in the drip, Rektalno.vnutri : 1 capsule (zapiwati few liquid), or 20 drops (with a small amount of water in lojecke); With little effect in 30 to 60 minutes Powthorno.p / to the in / m and / drip in : the dose of 50-100 Mg.rektalno : 1 suppozitoriu deep in the rectum 2-3 times per Sutki.sutocnaya dose of no more than 400 mg (160 drops, eight capsules, eight vials of 50 mg or 4-under 100 mg). Children from 1 to 13 years : inside (in the form of solution) at the rate of 1-1.5 mg / kg (4-6 mg / kg / day).

Storage conditions

caps. : List B. In the dark place at a temperature of 15-25 ° Cr-r d / in. : List B. In the dark place at a temperature of 15-25 ° Cr-r reception inside : In the dark place at a temperature of 15-25 ° Csupp.rekt. : In the dark place at a temperature of 15-25 ° C

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