Obsluga

Chemical name

транс-({+})-2-[(Диметилам��но)метил]-1-(3-метоксиф��нил)циклогексанол (as hydrochloride)

Gross

C16-H25-N-O2

Characteristics

The white crystalline powder, odourless, bitter taste, well-soluble in water and ethanol.

Of drugs

The drugs-analgezirutee (drug). Activates Waismann receptors (mu-, delta- and kappa-) for the pre - and postsinapticakih discs MUP fibers notsytseptivna system, brain and blood; To the opening of potassium and calcium channels is giperpoliarizatia membranes and down the nervous system. Wrinkles destruction of catecholamines and stabilizes them in the central nervous system. Analgeziruty effect is the reduction of notsytseptivna and increase antinozizeptivna-of the body's systems. Sedativo affects the bark cord injures kashleva and breathing centers, brings a fleeting vomitoxin centre, the nucleus glazodwigatelnogo nerve; It causes smooth muscle Sfinkterov.posle intake of fast and complete skin (90%), absolute bioavailability for 68%. C_max achieved in 2 hours Is the plasma protein by 20%. The distribution depends on the method and the introduction of 306 and 203 litres after oral or / with the introduction respectively. Passes through GEB etc. gistogematicalkie barriers, including placental, secretiruetsa in breast milk. Biotransformation is in the liver by demethylation and conjugation with the formation of 11 metabolites (1 of them active). Excreted mainly kidneys (90%) and gastrointestinal (10%). If any of the liver and kidney (Cl creatinine less than 80 ml / min) down off.

Indications

Pain syndrome average in malignant tumors, acute myocardial infarct, injuries, diagnostic and therapeutic procedures neuralgia.

Contraindications

Hypersensitivity, acute alcohol poisoning and intoxication deprimirutmi means and preparations oppressive CNS, epilepsy, disruption of the liver and kidney failure, pregnancy, breast-feeding (at the time of treatment is halted), a children's early age (up to 2 years).

Side-Effects

Dependence, the syndrome of "lifting" addictive, dizziness, block, respiratory depression, dysphoria, euphoria, reduction of cognitive abilities, convulsions, vomiting, tachycardia, palpitation, hypotension, collapse, nausea, pain in the area epigastralna, vomiting, constipation, difficulty urinating, allergic reactions.

Patient interaction

Do effects of tranquilizers, hypnotics, sedatives and anaesthesia means Alkoghola.aguosti reduce analeptiki psihostimulatora and completely block-naloxone n naltrexone (direct antagonists). Coupled with neiroleptikami can cause convulsions.

Overdosing

Symptoms : respiratory depression, until patients, convulsions, reduced pupil, anuria, Koma.lechenie : introduction naloxone (specific antagonist), in / in the washing stomach, maintaining vital functions.

Dosing and Administration

Inside adults and children over the age of 14-50 mg (again not earlier than 30 to 60 minutes). Dropped 100-mg, rektalno-100 mg (reinstate candles possibly through 3-5 h). The maximum daily dose is 400 mg. Children between the ages of 2 and 14 years inside (drops) or parenteral 1-2 mg / kg

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