Tramal retard

Roman name

Tramal retard #

The composition and the form of

1 tablet contains retard tramadol hydrochloride 100, 150 or 200 mg; blistere in 10 pcs. , in the box one blister.

Characteristics

Analgethick opioid.

Of drugs

Analgezirutee. Waismann stimulates receptors reduces reverse sinapticeski hostage norarenalina and serotonin.

Pharmacokinetics

Extracted from the blood of more than 90%, material 68%. C_max achieved in 4-5 hours Linking blood protein 20% T_1/2 - 12h, in patients over 75 years of age and with liver failure is increasing. Metabolised in the liver, excreted (unchanged to 30% and in the form of metabolites 60%) kidneys.

Clinical pharmacology

The developed in 15 minutes; It is oppression respiratory centre and the cardiovascular system. In a controlled drug dependency is rare, and much less pronounced than morphine.

Indications

The acute and chronic expressed moderate pain syndrome (including the elderly and those with breathing difficulties) : in malignant tumors, trauma, pain caused by myocardial infarction, nevralgiah, diagnostic and therapeutic procedures. Prevention controlling pain in predoperatinom period.

Pregnancy and lactation

Perhaps only for health reasons, the application is limited to a single reception. When feeding about 0.1% rate is in breast milk, but after a single dose of it is not necessary to interrupt breast-feeding.

Contraindications

Hypersensitivity; Alcohol intoxication, drugs means analgezirutmi or other drugs acting on the central nervous system; Syndrome abolishing drugs; Pregnancy, breast-feeding mothers, children's age (up to 14 years).

Side-Effects

From the nervous system and sensory organs : dizziness, headache; Rarely zatumanennosti view, the change in mood, activity, the perception (behaviour of the senses); In a few cases -epileptiformnye convulsions (to high doses or in combination with antidepressants or antipsychotic drug), may develop "the syndrome." For part of the intestine : nausea, vomiting, constipation; rarely pains in the abdomen, the feeling of overcrowding in the stomach, appetite changes; in a few cases, the increased levels of liver Fermentov.so the circulatory system and blood (blood, gemostaz) : rarely palpitation, tachycardia, and gipotenzia ortostaticeski collapse; in a few cases, the AD Bradikardia.so the Skin : rarely feature, Sapi.so the urogenital system : in a few cases, violations Mocheispuskania.so the respiratory system : perhaps astmasticski deterioration of the state, sometimes suppress respiration (at high doses or combinations of drugs, oppressive CNS). Allergic reactions : rarely urticaria, breathing problems, bronhospazm, asthma component angioneuroticeski swelling, anaphylacticskie Reaktion.prochie : rarely muscle weakness.

Specific guidance

People with a tendency to abuse drugs or drug addiction appointed only if there is direct testimony short and under constant medical supervision.

Patient interaction

Incompatible with MAO inhibitors. Do (mutually) effect of tranquilizers and sleeping. Carbamazepine (including in the preceding admission) reduces the intensity and duration of pain relief. Poorly effects of analgesics агонистов/антагонист��в opioid receptors. Selective inhibitors over serotonin, tritziklicicakie antidepressants, antipsihoticalkie means inducyruut convulsions.

Overdosing

Symptoms : respiratory depression, convulsions, reduced inhibition, Koma.lechenie : measures Emergency - aspiration, maintenance respiration and the cardiovascular activities washing stomach. Opioid effects kupiruyutza naloxone, convulsions, drugs from the group of benzodiazepines Haemodialysis and gemofiltration ineffective.

Precautions

Be wary appoint patients with a heightened sensitivity and drug dependence on opioids, with shock, confusion ambiguous genesis, human breathing, increased vnutricerepnom pressure. The epilepsy drug appoint only for health reasons. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, regardless of eating pills With the whole, not liquid, with a sufficient quantity of liquid. Establish dose depending on the intensity of the pain and self - переносимости.Взросл��м and adolescents over 14 years of age-100 mg (1 tab). twice a day (morning and evening). In the event of an insufficient effect on the 150 or 200 mg, brought between devices is not less than 6 hours The maximum daily dose is 400 mg. Unlike the minimum effective dose; single dose, up to 200 mg daily to 400 mg. In patients older age (75 years or more) and patients with diseases of the kidneys and liver increase the interval between meals single doses in accordance with the patient's spirits.

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