Transtech

Roman name

Transtec

The composition and the form of

1 trancdermalnaya therapeutic system contains buprenorphine 20 mg (speed release of 35 µ g / h, the area containing the active substance, and 25 cm ^ 2); 30 mg (speed up 52.5 µ g / h, the area containing the active substance, and 37.5 cm ^ 2) or 40 mg (speed release of 70 µ g / h, the area containing the active substance, and 50 cm ^ 2); in the package, 3 5 or 10 individually packaged trancdermalnah therapeutic systems.

Characteristics

Hanna rectangular with rounded corners to aluminizirovannom hard remove protective layer to the physical basis of colour. At the heart of a tank-matrix product. Appearance matrix containing the active substance, brown adhesive mass shown on the cloth strips.

Pharmacokinetics

After sealing trancdermalna therapeutic system buprenorphine absorbed through the skin (regular and steady flow of the active substance in the body adgezivna polymer matrix system). The concentration of plasma gradually increases, the minimum effective level is a 12 to 24 h at 100 pg / J For Transteka ® 35 µ g / h S_max is 305 pg / ml and is a 57 hour, for Transteka ® 70 µ g / h-624 pg / ml and is a 59-hour Linking plasma protein is 96%. Metabolised in the liver. Provided through the intestine and kidneys. Passes through GEB and placental barrier. T_1/2-30 p.m.

Farmakodinamika

On farmakologicakomu act as potent as morphine in the 25-50 times. To a lesser degree than morphine, oppressing breathing center, as dangerous for the development of drug addiction in the long-term use.

Indications

Therapy medium and expressed strong chronic pain in oncology, pain syndromes, not kupiruthan nenarcoticakimi analgetikami.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, physical drug dependency, oppression respiratory centre, reception MAO inhibitors, pregnancy, breast-feeding, age to 18 Let.s caution, with respiratory failure, kidney and / or liver failure, miksedeme, gipotireoze, insufficient napochechnikov, oppression CNS, head trauma, toxic psychosis, hyperplasia prostate, the urethra stricture, Alkilizme.s utmost care, with acute alcohol intoxication convulsions, head trauma, loss of consciousness ambiguous genesis, vnutricerepnom increased pressure.

Side-Effects

Nausea, vomiting, sweating, dry mouth, headache, depression, a decline AD breath, block, oppression breathing centre slowing of mental and motor reactions, skin rashes.

Specific guidance

During treatment is not recommended to engage in activities requiring concentration and psychomotor speed reactions.

Patient interaction

Incompatible with MAO inhibitors. Potenziruet the narcotic analgesics, fenotiazinov, anxiety, sedatives, hypnotics assets, general anaesthetics alcohol.

Storage conditions

The temperature does not exceed 25 ° C

Shelf life

3 years

The registration

015004/01-2003

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