Trimeperidine

Chemical name

1,2,5-Триметил-4-фенил-4-п иперидинол propanoat (ether)

Gross

C17-H25-N-O2

Characteristics

The white crystalline powder. Easily soluble in water, soluble in alcohol. Aqueous solutions have pH 4.5.

Of drugs

The drugs-analgezirutee (narcotic), protivosokowoe, pills, skin, uterotonizirutee. Does opioid receptors in the central nervous system. The on / in a C_max (9 µ g / ml) is achieved in 15 minutes, and then a rapid decline in plasma and after 2 h defined only sledove concentration. Compared with morphine to a weak and short of analgesia, less impact on the breathing, and emetic wagusny centres, it is acute smooth muscles (except Oxytocics) is a moderate and herbal pills effect. When s / c and / m to a starting 10 to 20 minutes and lasts for three to four hours or more; Ingesting a analgeziruty effect 1.5-2 times weaker than injecting a similar dose.

Indications

Expressed pain syndrome (unstable stenocardia, myocardial infarction, rasslaivataya anevrizma arteries, coronary renal artery tromboembolia arteries limbs and pulmonary artery, acute pericardit, air embolism, pulmonary infarction, acute pleurisy, spontaneous pneumothorax, saying disease stomach and duodenal ulcers, perforation of the oesophagus, chronic pancreatitis, liver and kidney kolica, paranefrit, the acute dizuria, foreign body bladder, rectum, the urethra, parafimoz, priapizm, acute prostatitis, acute glaucoma attack, kauzalgia, acute neuritis, sciatica sciatica, acute vezikulit, talamicheski syndrome, burns, trauma protorgia intervertebral disc, malignant neoplasms, posleoperazionny period), the acute levojeludochkovaya failure, pulmonary lung cardiogenny shock preparations for the operation (premedikation), birth (pain and stimulation), a high fever, posttransfuzie complications poisoning atropinom, barbituratami, bariem, gas, boric acid, strong acids, carbon dioxide, skipidarom, formalin, the bite of snakes karakurt.

Contraindications

CHD insufficient, the overall attrition, early child (up to 2 years) and aged age.

Side-Effects

Nausea, vomiting, weakness, dizziness, breathing oppression centre addiction, physical dependence.

Patient interaction

Compatible with neirolepticakimi, antihistamines preparations holinolitikami, miotropnami spazmolitikami, galoperidolom, droperidolom.

Dosing and Administration

P / to the in / in, in m-1 ml of 1% or 2% solution; The maximum dose for adults : single - 0.04 g daily, 0.16 inside the city, on 0,025-0,05 g; Children (over 2 years) for 0,003-0,01 g per reception.

Directory → Neurotropic funds → Opioids, their analogues and antagonists → Trimeperidine