Benzobamil

Chemical name

1-Бензоил-5-этил-5-изоам илбарбитуровая acid

Gross

C18-H22-N2-O4

Characteristics

Derived barbiturova acid. The white crystalline powder gorkovatogo taste, odourless. Virtually nerastvorim in water, easily soluble in ethanol.

Of drugs

The drugs - противоэпилептическо е. Provides protivosudorozhnoe, sedative, and in high doses pills действие.Противоэпил��птический effects due to the interaction with the receptor Gamk_a-retseptonego complex disclosure neironalnah channels for chlorine ions, increase their income nervous cells and the relaxation of neuronal excitability. Has impact on potencial-zawisimae sodium channels (inachtiwatia increases), and inhibits the release of glutamate glutamatergicakih aguiruth neurons.

Indications

Epilepsy : all forms, including podkorkova to contain any fire, diengjefalnaya, apparently status of children; korkove and bessoudorozhnye forms of epilepsy (less effective).

Restrictions on the use of

Arterial gipotenzia.

Contraindications

Hypersensitivity Arterial gipotenzia, lesion of the liver and kidney with a violation of their functions, cardiac decompensation activities.

Side-Effects

Drowsiness, weakness, depression, loss AD addictive.

Specific guidance

The application, together with degidratatini, противовоспалительно й desencibiliziruta and therapy.

Patient interaction

Is mikrosomaionah inducer of the liver and can reduce the concentration of plasma used drugs at the same time, including protivosudorozhnykh.

Precautions

Treatment is long-term and continuous. In developing adjusting benzobamil you can combine with equivalent doses of phenobarbital and benzobarbitala followed by the replacement of their benzobamilom again. To reduce the appearance side effects can be used during the daytime caffeine or lower doses of the replacement of the other противоэпилептически м tool. Estimated ratio equivalent doses benzobamila and phenobarbital is 2:1. Patients who had other anti drugs into treatment benzobamilom out gradually at the same time increasing the dose benzobamila and reducing the dose previously designated product (to avoid frequent seizures). Benzobamila lifting a gradually decreasing doses time (under the supervision of clinical), but no earlier than two years after the end of the Pripadkov.sleduet that barbiturates belong to the category of funds for which there is evidence of the risk of adverse effects on the fetus during pregnancy, but the potential benefits to the mother may justify their use, despite the potential risk to the fetus.

Dosing and Administration

Inside, the food picked dose individually. The average single dose for adults-25 mg (if necessary increase to 50-200 mg), the maximum single dose of 300 mg, taken three times a day. For children, according to the age of 50 mg to 100 mg per reception three times a day.

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