Benzobarbital

Chemical name

1-Бензоил-5-этил-5-фенил барбитуровая acid

Gross

C19-H16-N2-O4

Characteristics

The white crystalline powder bitter taste. Very little is soluble in water, it is difficult in alcohol.

Of drugs

The drugs-protivosudorozhnoe, nursing, sedative. Do brake Gamkergicakie influence in the central nervous system, particularly in talamuse, upstream activating retikuliarna formations barrel brain at the level of neuronal inserted. Reducing permeability membrane of nerve fibers for sodium ions, reduces the rate of epiocaga. Rapidly absorbed from the intestine and metabolized to phenobarbital (is thus prolekarstvom) and then oxidized by mikrosomalna zitohroma P450. Weak associated with plasma proteins. Creates high concentrations in the brain, liver and kidneys. Penetrates gistogematicalkie through barriers and breast milk. The effect is a 20-60 minutes after enteralnogo reception. T_1/2 is 3-4 days. Excreted kidneys in unaltered, and in the form of metabolites.

Indications

Various forms of epilepsy, giperbilirubinemia, haemolytic disease of newborns, insomnia.

Restrictions on the use of

Hypotension, pregnancy, breast-feeding (at the end of treatment).

Contraindications

Hypersensitivity, porphyria, anaemia, bronchial asthma, respiratory distress, disruption of the liver and kidney failure, diabetes mellitus, Ray, napochechnikovaya deficiency, diabetes mellitus, giperkineza, depressive state (with suicidal attempts).

Side-Effects

Adjust, drug dependence syndrome "lifting" of the liver and kidney failure and respiratory depression, bronhospazm and hypotension, thrombocytopenia, anemia, throm, headache, dizziness, weakness, depression, refers, giporeflexia, allergic reactions.

Patient interaction

Do effect analgesics, anesthetics, gipnotikov, of narcosis, Neuroleptics, tranquilizers, tricyclic antidepressants, alcohol reduces - paracetamol, anti, tetracycline, grizeofulvina, glucocorticoids, mineralokortikoidov, cardiac glycosides, hinidina, vitamin D, xantinov.

Dosing and Administration

Inside. For adults to 0.1-0.2 g three times a day after meals. The highest single dose of 0.3 grams, the highest daily intake - 1 G.dla children : 3-6 years, 25-50 mg per intake (100-150 mg / day), 7-10 years is 50-100 mg per intake (150-300 mg / day), 11 to 14-100 mg per intake (300-400 mg / day). The highest single dose-150 mg, the highest daily dose of 450 mg.

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