Bromocriptine

Chemical name

(5'альфа)-2-Бром-12'-гидро кси-2'-(1-метилэтил)-5'-(2-��етилпропил)эрготаман - 3 ',6' ,18-trion (in the form of nelfinavir)

Gross

C32-H40-Br-N5-O5

Characteristics

Polusinteticescoe alkaloid derivative LPV ergokriptina (2-бром-альфа-эргокрип��ин). Crystalline powder, very little soluble in water, sparingly soluble in ethanol.

Of drugs

The drugs - противопаркинсоничес кое. Does dofaminove D_2-retseptora Brain. Ingibiruet incretia prolactin and suppresses physiological lactation, normalizes menstrualnuu function; Dofaminergicescuu facilitating transfer nigrostriarna system reduces the severity of symptoms parkinsonizma; Reduces somatotropina concentration in the blood in patients akromegaliei reduces depressivnuu Simptomatiku.posle intake of rats 30%. It is important to effect "the first passage" through the liver. C_max blood is 2-3 hours Connectivity albuminami plasma-90-96%. Write mainly jelchew (86%), with the urine-only 2.5%.

Indications

Infertility and dismenorea against giperproduktion prolactin, giperprolaktinemia (including as a result of receiving psychotropic and antigipertenziveh cent), post lactation (with the need to suppress), akromegalia, benign node or kistosnye changes mammary glands, parkinsonism.

Restrictions on the use of

Erosivno-azwenne shock syndrome, pregnancy (I term). Be wary appoint persons whose work requires more attention, and speed of decision-making.

Contraindications

Hypersensitivity, gipotenzia recently moved myocardial infarction expressed in rhythm, mental illness.

Side-Effects

Nausea, vomiting, constipation, reducing AD pobelenie his hands and feet at cooling, headache, swelling of mucous membranes. Seldom-ortostatical gipotenzia, collapse.

Patient interaction

Incompatible with MAO inhibitors and alcohol. Reduces effect doses, oral contraceptives, reduces akineziu caused rezerpinom.

Dosing and Administration

Inside, at the time of delivery. Assign 2.5 mg twice a day for 10-17 Dnei.v gynaecological practice in the Gulf galactorei-amenorei, razvivchemsa after childbirth, lung cancer and barrenness due giperprolaktinemiei-on the 1.25 mg 2-3 times a day for 3-6 Mes.pri disease Itsenko Kushinga-in the early days of taking 7.5 mg / day, then reduce the dose to the vessel mg / sut. After 2-3 weeks are in the process of approving the dose of 2.5 mg / day Course 6-8 Mes.pri akromegalia appoint 5-10, in-parkinsonizme 30-40 mg / sut.

Directory → Neurotropic funds → Противоэпилептически е means → Bromocriptine