Ethosuximide

Chemical name

3-Этил-3-метил-2,5-пиррол идиндион

Gross

C7-H11-N-O2

Of drugs

The drugs-protivosudorozhnoe, miorelaksirutee, analgezirutee. Oppressing motor cortex centres large brain, increases sudorozhny threshold. Quickly and almost completely absorbed from the digestive tract; C_max blood achieved through 1-4 hours Therapeutic concentration of 40 µ g / ml; Presented mostly in the urine. It is associated with blood plasma proteins (0-5%). T_1/2 adults-60 hours, the children, 30 hours Easily passes gistogematicalkie barriers; Level in the spinal fluid is such plasma. Penetrates through the placental barrier and breast Moloko.snijaet Frequency small stroke epilepsy, epileptiformnah attacks suppresses paroxysmal электроэнцефалографи ческую activity, in association with the characteristic of absansov human consciousness. Effective when mioclauniceskih attacks. The full effect is usually achieved through 4-8 weeks.

Indications

Various options for small stroke primary and secondary generalized epilepsy, in some cases, with mioclauniceskih attacks.

Contraindications

Hypersensitivity, liver and kidney failure, pregnancy, breast-feeding (optional waiver of breastfeeding).

Side-Effects

Nausea, vomiting, decrease in appetite, icota, pain in the abdomen, diarrhoea, treatmentoptions, headaches, dizziness, irritability, euphoria fotofobia, skin rashes, girsutizm, insomnia, anxiety, lack of concentration, aggressiveness; Rarely the blood (neutropenia, agranulozitos, eozinofilia, pancitopenia, aplastic anaemia) albuminurija, mikrogematuria, plant red systemic lupus, parkinsonism, miopia; in some cases, �араноидально-галлюци наторные symptoms, the development of large seizures.

Patient interaction

Wrinkles biotransformatia difenina in the liver increases its concentration in the blood (can develop eye, ataxy, giperplazia gums). Carbamazepine accelerates metabolism and reduces the plasma. Significantly alter the level (decreases or increases) etosximida blood valproeva acid. The risk of toxic effects increases isoniazid.

Overdosing

Many nausea, vomiting, oppression CNS (until Tuesday), disorder Dahania.lechenie : washing stomach, activated carbon, laxatives; Can be used dialysis (giving diureza obmennoe and blood transfusions are not effective).

Precautions

It periodic determination of the concentration of plasma to adjust the dose, especially while others admission protivosudorozhnykh funds. The treatment should monitor kidney function and liver (pechenocnae enzymes, creatinine, urea, total urine), the common blood (at the same time bear in mind that emerging hematologic changes can mask the characteristic picture of infectious diseases). During treatment should refrain from activities potentially hazardous activities that require immediate response and greater attention, as well as to exclude the admission of alcohol.

Dosing and Administration

Inside, the initial dose for children 3-6 years old is 250 mg / day in one leap, six years and over-500 mg / sut. Dose increase gradually every 4-7 days with a maximum dose of 1.5 g; Optimal daily intake for children - 20 mg / kg, for adults, 15 mg / kg

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