Klonazepam

Roman name

Clonazepam #

The composition and the form of

1 tablet contains klonazepama 0.5 or 2 mg; blistere in 30 pcs. , in the box one blister.

Of drugs

Protivosudorozhnoe, protevoepilepticescoe, miorelaksirutee, anxiolytic, sedative. Decreases anxiety subcortical areas of the brain (limbical system Diencephalon, dystonia), and violates their interaction with the crust. Oppressing polisinapticalkie spinale though.

Pharmacokinetics

Quickly and completely absorbed in the digestive tract. Once inside C_max achieved in 1-2 hours T_1/2 - 18-50 h. Write mainly via the urine.

Indications

Epilepsy in children and adults (akinetical, mioclonica, Generalized submaximale, visocnae fokale and seizures); Syndromes paroxizmalnogo fear, anxiety (in patients over 18 years of age); Maniacal phase ticlotimii, agitation and psihozah jet.

Pregnancy and lactation

When pregnancy is permitted only on an absolute statement. Nursing mothers should stop breast-feeding.

Contraindications

Hypersensitivity, human consciousness, breathing (central origin), respiratory distress, glaucoma, infants, severe disorders of the liver, the age to 18 years (paroxizmalnom fear).

Side-Effects

Drowsiness, dizziness, ataxy, discoordination, a sense of fatigue, weakness, memory, speech, the disorder, anxiety, a reduction in the ability of learning disabilities, emotional lability, lower libido, disorientation, depression, the symptoms kataralnogo inflammation of the upper respiratory tract, gipersalivacia, constipation, pain in the abdomen, a decline of appetite, muscle pain, menstrual irregularities, frequent urination, eritro-, leiko- and thrombocytopenia, increase concentration in the blood transaminaz and alkaline phosphatase, paradoxical reaction, the institution, insomnia (call for the elimination of the drug), allergic skin manifestations.

Patient interaction

Increases effect barbiturates neiroleptiki, antidepressants, anticonwulsanta, narcotic analgesics, alcohol, means less muscle skeletal muscles; Reduced-nicotine. Alcohol cause paradoxical reactions : agitation or aggressive behaviour, possibly of pathological intoxication.

Precautions

Be wary appointed to the human kidney and liver, chronic respiratory system in older age (over 65 years). Prolonged use leads to a weakening of action. Do not drink alcohol at the time of treatment in the past three days after its completion. Denial dose therapy reduces gradually, as a odnomomentnoe reception (especially after a long course) can lead to the development of mental dependence and a withdrawal syndrome. The treatment can not be controlled vehicles and service moving mechanical devices.

Dosing and Administration

Inside. Epilepsy : adults, the initial dose of 1.5 mg / day in 3 reception, followed by an increase of 0.5-1 mg every 3 days supporting-dose 4-8 mg / day in the reception 3-4; The maximum dose of 20 mg / day; Children, the initial dose of 1 mg / day in 2 reception then increased by 0.5 mg every 3 days supporting dose in children under five years of age are 1-3 mg, 5 to 12 years, 3-6 mg / day, the maximum dose of 0.2 mg / kg / Sut.sindrom paroxizmalnogo fear in adults : 1 mg / day (up to 4 mg / day).

Storage conditions

table. : In the dark and wet ground so that the temperature does not exceed 25 ° C

Shelf life

table. : 3 and

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