Conwuleks

Roman name

Convulex #

The composition and the form of

1 capsule, coated kishechnorastvorima liner contains valproeva acid 150, 300 or 500 mg; in a contour acheikova packing 10 pcs. (150 and 500 mg), or 20 pcs. (300 mg), in a box 10 (150 and 500 mg) or 5 (300 mg) upakovok.1 ml syrup for children 50 mg; Milk in 100 ml, complete with metering stakanchikom in box 1 ml complekt.1 drops reception inside (30 drops), 300 mg; Milk in 100 ml, in the box one bottle.

Of drugs

Противоэпилептическо е. Ingibiruet Gamk-transferzu and enhances the GABA in the brain tissue, reduces anxiety and sudorojnuu motor activity of the brain.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract, bioavailability is about 93%. Completeness rezorbtion not dependent on the diet. C_max determined after 1-3 hours, and admission capsules covered kishechnorastvorima-coated every 2-3 hours Equilibrium concentration is at th day of the treatment (depending on the dosing intervals). Therapeutic concentration in plasma is 50-100 mg / J 80-95% drug binds to plasma proteins. Metabolised in the liver by glukuronirovania and oxidation. T_1/2 alone with 20-hour, and combination therapy on 6-8 hours Report the news in the form of metabolites and unmodified form (1-3% dose).

Indications

Epilepsy, epileptic seizures : Generalized small ochagove (stiffness) with a simple and complex symptoms; Conduct disorders (related to epilepsy); Sudorozhny syndrome and organic brain diseases; Febrile convulsions and brain practice in children.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy; At the time of treatment should be suspended breastfeeding.

Contraindications

Hypersensitivity, the liver and / or the pancreas, bloody diates.

Side-Effects

For part of the intestine : Diarrhoeal disorders, nausea, vomiting, anorexia and bulimia, the liver and pancreas, increased body mass index, pain and cramps in the stomach, diarrhoea or Zapor.so the nervous system and sensory organs : dizziness, weakness, ataxy, tremor, depressed, sputannoe Soznanie.so the circulatory system and blood (blood, gemostaz) : rarely thrombocytopenia, anemia, lakopenia (neutropenia), gipofibrinogenemia, prolonged bleeding, the propensity to petehiam and Gematomam.prochie : alopecia, the menstrual cycle (amenorea, dismenorea), the increase in body mass index, skin rashes.

Patient interaction

Do effect doses, drugs, alcohol, antiagregantov (acetylsalicylic acid) and anticoagulants. Phenytoin, phenobarbital, carbamazepine and primidon weaken anticonwulsivne influence salicilata-reinforcing.

Overdosing

Symptoms : coma hypothesis or areflexia central oppression Dahania.lechenie : washing stomach, the appointment of activated carbon Hepatology, diurez big, the maintenance of respiratory and cardiovascular activities.

Precautions

Be wary when using anamnesticeskih data on the diseases of liver and pancreas, liver, bone marrow, violations of the kidney, congenital enzimopatiah, heavy forms of convulsions stroke, organic lesions in the brain, the mentally retarded children, children under the age of 2 years (high risk of liver damage). During treatment reception avoid alcohol. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. Termination treatment should gradually to avoid syndrome lifting. "

Dosing and Administration

Inside, during or after delivery, capsules is not liquid, squeezed small amounts of liquid drops and syrup, mixing with a small number (drop-quantities) of the liquid. Initial daily doses of 15 mg / kg Multiple reception, 2-3 times a day. Dose gradually increased to 10 mg / kg per week to achieve clinical effects. The average daily intake in the body weight 7,5-14 kg to 150-450 mg / day, 14-21 kg-300-600 mg / day, 21 to 32 kg, 600 mg / day, 32-50 kg-huge mg / day, 50 to 90 kg, 2,500 mg / sut.

Storage conditions

Drops for reception inside : List B. In dry the dark place at a temperature of 15-21 °Cкапс.раствор./кишечн . : List B. In dry the dark place at a temperature of 15-21 ° Csirop detsk. : List B. In dry the dark place at a temperature of 15-21 ° C

Shelf life

Drops for reception inside : 5 леткапс.раствор./кише��н. : 5 letsirop detsk. : 5 years

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