Konwulsofin

Roman name

Convulsofin

The composition and the form of

1 tablet contains digidrata limestone salt valproeva acid 333 mg (equivalent to 300 mg limestone salt valproeva acid), as well as auxiliary substances-gelatin, potato starch, a besieged silicon dioxide, talc, magnesium stearate; in vials of 100 pcs. , in the box one bottle.

Pharmacokinetics

Once inside the tiny sprouts of calcium valproata formed free valproeva acid, which is rapidly absorbed. C_max achieved through 3 hours; Therapeutic concentration in plasma from 50 to 100 µ g / J Linking plasma protein-90-95%. Metabolised education gidrauxilirovannah derivatives valproeva acid. T_1/2 with monotherapies - 12-16 hours

Indications

All forms of epilepsy. Epileptic seizures : Generalized (absansa, mioclauniceskie tonico-klonicakih or convulsions), stiffness, вторичногенерализиро ванные.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. In the first quarter, especially between 20 and 40 day of pregnancy, appointed the lowest dose. During the period of treatment of breast-feeding is not required.

Contraindications

Hypersensitivity expressed human liver and pancreas, gets defeated in liver disease (including family), porphyria, a breach of blood clotting.

Specific guidance

The risk of taking human liver increased in children under 18 months with severe epileptic (apply only to monotherapies). If any of kidney daily dose decreased. Going to therapy Konwulsofinom are slowly, gradually decreasing dose of the previous product. In appointing at the same time as the others. противоэпилептически ми of the last dose, especially phenobarbital, should be reduced. Against the backdrop of possible treatment absorption reaction to the ketonovykh bodies in the urine.

Patient interaction

Do effect pills and sedated, doses, antidepressants, including MAO inhibitors; increases barbiturates concentration in plasma. Anti drugs (phenobarbital, phenytoin, carbamazepine) decreased activity gepatotoksicnae and ethanol make toxic effect on the liver. The combined application with antikoagulyantami and acetylsalicylic acid increases the risk Krovotecheni.pri appoint a PP containing valproevu acid and clonazepam, in patients with small seizures absansov type in the history evolved absansa status.

Overdosing

Symptoms : perhaps the increasing incidence described side effects.

Precautions

With the utmost care and under close medical supervision appoint patients with congenital enzyme deficiency diseases bone marrow in history, human blood clotting, the younger ones, especially in the wake of others противоэпилептически х funds. A periodic monitoring of liver activity transaminaz level cium, total protein fibrinoguena plasma blood amylase in the urine, tromboplastinovogo time. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. At temperatures below 30 ° C

Shelf life

5 years

The registration

014780/01-2003

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