Directory → Neurotropic funds → Противоэпилептически е means → Lamictal
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LamictalSee also LamotrigineRoman nameLamictalPharmacokineticsLamotridgin rapidly and completely absorbed from the intestine. C_max plasma is approximately 2.5 h after administration of the drug inside. T_max increase slightly after meals, but the level of absorption is неизменным.Фармакоки��етика is the linear nature of the admission dose to 450 Mg.stepen lamotrigina bonding with the plasma protein-about 55%. The distribution 0,92-1,22 l / metabolism Kg.v lamotrigina participates enzyme глюкуронилтрансфераз а. Lamotridgin does not affect the other farmakokinetiku противоэпилептически х Preparatov.u adults Cl lamotrigina averaged 39 ± 14 ml / Min.lamotridgin metabolised to glukuronidov that derived from urine. Less than 10% of drugs is the urine unchanged to about 2% from faeces. Cl T_1/2 and do not depend on Dozy.cl lamotrigina calculated by the body mass index, higher in children than in adults; It is highest among children under 5 years of age. Children T_1/2 lamotrigina usually shorter than that of Vesroslah.imetesa data indicated no significant differences in Cl creatinine in patients older than young Patientami.srednie of Cl lamotrigina for patients with chronic renal failure and patients in gemodialise of 0.42 ml / min / kg (chronic kidney failure), 0.33 ml / min / kg (between dialysis sessions), and 1.57 ml / min / kg (during dialysis). Average T_1/2 amounts to 42.9 hours, 57.4 hours and 13 hours During the hour dialysis session of the body to return about 20% lamotrigina. Thus, in violation of the kidney initial dose lamotrigina calculated in accordance with the standard layout appointment противоэпилептическо го preparation; for a patient with a significant decline in kidney function that supports lowering rates Dozy.srednie Cl lamotrigina in patients with impaired liver light, moderate and severe (stage A, B and C on Child-piu) are 0.31, 0.24 and 0.1 ml / min / kg, respectively. Elementary, and the increasing supporting dose should be reduced by approximately 50% in patients with moderate hepatic insufficiency (Stage B) and 75% with severe (Stage C). Elementary and increasing dose to be adjusted depending on the clinical effect.IndicationsPartial and Generalized seizures, including tonico-clauniceskie and the syndrome Lennox-Gastaut (adults and children), bipolar disorders in adults over 18 years of age with a predominantly depressive phases.Pregnancy and lactationSince lamotridgin a weak inhibitor digidrofolatreduktaza, there is at least a theoretical risk of birth defects in the foetus in the employment drug during Beremennosti.dl order to assess security lamotrigina of pregnancy, data Nedostatern.v Currently, the information on the application to lamotrigina Association Nepolnaya.lamotridgin determined in breast milk in concentrations of the 60% of its concentration in the plasma. Some children who are breastfed - lamotrigina concentration in the plasma reaches therapeutic.ContraindicationsГиперчувствительност ь.С caution should be appointed in case of renal failure.Patient interactionПротивоэпилептически е drugs (phenytoin, carbamazepine, phenobarbital, primidon) Paracetamol up metabolism lamotrigina and cut its T_1/2 2 Raza.poscolku valproat competitive metabolised pechenocnami enzymes, it is slowing metabolism lamotrigina and increases its T_1/2 to 70 hours in adults and up to 45-55 hours to Detei.pri accession to the therapy carbamazepinom lamotrigina possible dizziness, ataxy, diplopia, clear vision and nausea, disappearing at lower doses Carbamazepina.pri accession to the therapy glukonatom aqueous lithium dose of 2 g twice a day for 6 days in lamotrigina dose of 100 mg / day, farmakokinetika lithium not Narushaetsa.povtornyi reception bupropion has not had significant effects on farmakokinetiku lamotrigina after taking one dose except for a small increase of AUC for lamotrigina glukuronida.PrecautionsExcept as otherwise provided in the patient requires immediate lifting of the drug (for example, when the skin vsapani) Lamiktala dose should be reduced gradually, over a period of two years Ned.v treatment to refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.Storage conditionsB. List in a dry place so that the temperature does not exceed 30 ° CShelf life3 yearsThe registration014213/01-2002 |
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