Primidone

Chemical name

5-Этилдигидро-5-фенил-4, 6(1H,5H)-пиримидиндион

Gross

C12-H14-N2-O2

Characteristics

The white crystalline powder. Virtually nerastvorim in water, air and benzene; Very soluble in ethanol and acetone.

Of drugs

The drugs-protivosudorozhnoe, sleeping. Decreases neuronal excitability in epileptogennom home. Quickly and almost completely absorbed in the intestine, C_max through 3h Bioavailability-90%. The blood marginally associated with a protein (20%). The distribution 0,64-0,86 l / kg T_1/2 for plasma is 7-14 hours The liver of becoming a phenobarbital (15-25%) and fenilatilmalonamid (FEMA), both have metabolita противоэпилептическо й activity. Excreted news in the form of primidona (64%), phenobarbital (7%) and FEMA (5%). The blood should support therapeutic concentration of 12 µ g / ml, which is high ischemia convulsions stroke. In other forms of epilepsy (bessudorojnaya form polymorphic seizures, etc.) effect is not always a complex treatment.

Indications

Epilepsy different genesis, large seizures apnoea. Ochagove, mioclauniceskie, akineticalkie attacks (less effective).

Restrictions on the use of

Children and old age (some children and older patients reacted to primidon paradoxical criminal and motor concern).

Contraindications

Гиперчувствительност ь (incl. to barbiturates), renal and hepatic failure, anaemia, lakopenia, pregnancy, breast-feeding (it is necessary to abandon breastfeeding).

Side-Effects

Drowsiness, dizziness, headaches, fatigue, anxiety, nausea, vomiting, anemia, lakopenia, limfozitos, allergic reactions. Seldom-eye, ataxy, "volchanochny" syndrome, arthralgia, psychotic reaction; It is rarely megaloblastnaya anaemia. With long-term use, drug dependency.

Specific guidance

Can be used in the integrated protivosudorojna therapy. Lifting and replacement of a gradually. Reduces response driving, working with machinery. In the case of megaloblastna anaemia, discontinue use of and begin treatment with folic acid and / or vitamin B_12.

Patient interaction

Do (mutually) effect carbamazepina, difenina etc. protivosudorozhnykh funds.

Dosing and Administration

Inside, the food. Treatment starts with doses of 125 mg once, and then every 3 days for the daily dose increase to 250 mg for adults and 125 mg for children (up to nine years) to achieve the necessary effect. The maximum daily intake for adults-1.5 g, for children 1-g (2 admission).

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