Directory → Neurotropic funds → Противоэпилептически е means → Sabril
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SabrilSee also VigabatrinRoman nameSabrilThe composition and the form of1 tablet coated liner vigabatrina contains 500 mg; blistere in 10 pcs. , in box 10 blisters.Of drugsПротивоэпилептическо е. Yes irreversibly ingibiruet Gamk-transaminazou increases of GABA, the main brake central mediator in the brain tissue.PharmacokineticsQuickly and adequately absorbed in the digestive tract. Away does not affect the value, but somewhat slow speed removals. It binds to plasma proteins and is not linked to the zitohroma P450 in the liver. Concentrations of plasma and spinal fluid linearly dependent on the dose, but a direct correlation to the effectiveness not. The effectiveness is determined by the rate of resinteza Gamk-transaminaza. T_1/2 5-8 hours About 70% after one administered orally presented with urine in the first 24 hours in an unmodified form. When kidney failure Cl reduced proportionately Cl creatinine.IndicationsEpilepsy (with inefficiency etc. противоэпилептически х drugs).ContraindicationsHypersensitivity, pregnancy, lactation (for the period of treatment should suspend breastfeeding).Side-EffectsFrom the nervous system : arousal, anxiety, irritability, depression, aggressiveness, mental illness frequent seizures; Rarely parestesia violation of concentration, fatigue, tremor, apparently Status.so part of the view : movement, defects in the fields; Rarely peripheral retinal degeneration of the eyes, muscle nerve membranes.Patient interactionImpact fenitoina effect.PrecautionsRemove Sabril should gradually reducing the dose for a period of two to three weeks, a sudden withdrawal of the admission could lead to the resumption convulsing. If any fields of obligatory consultation ophthalmologist. Below this Cl creatinine less than 60 mL / min should be reduced doses.Storage conditionstabl.p.o. : List B. At room temperatureShelf lifetabl.p.o. : 5 years |
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