Vigabatr 218 in

Chemical name

4-amino-5-gexanova acid

Gross

C6-H11-N-O2

Of drugs

The drugs - противоэпилептическо е. Irreversibly ingibiruet transaminazou GABA, and increasing its content in the brain Mozge.bystro absorbed after administration inwards. Time to C_max about 2 hours It binds to plasma proteins, easily penetrate various fabrics, little is biotransformation. T_1/2 young patients, p 5-8, and increased with age until 12-13 hours The way out through the kidneys (24 hours excreted about 70%). If any of the kidneys of speed depends on the level of Cl креатинина.Продолжит��льность effect the intensity resinteza Gamk-transaminaza. Decreases Frequency partial seizures attacks by 50% or more, including in refrakternosti to normal противоэпилептическо й medication dosage nekurable infantile spasms.

Indications

Epilepsy : as a second dru 218 g to a partial attacks localizations home in subdominantne hemisphere Generalized fotosencitiveh attacks; Vesta syndrome, acute febrile convulsions (with inefficiency valproeva acid).

Contraindications

Hypersensitivity, psychotic reactions, including in history, mioclauniceskie convulsions, of the kidneys, pregnancy, breast-feeding (at the time of treatment is halted), old age.

Side-Effects

Drowsiness, increased fatigability, fatigue, reduced stiffness, headache, dizziness, anxiety, depression, memory, diplopia and other disorders of ag 218 gression, ataxy, disorientation, insomnia, reduced concentration, ajitation, anxiety, emotional lability, irritability, tremor, movement, human gait, speech, increasing seizures, psychosis, pain in the abdomen, constipation, nausea, vomiting, gipersalivacia, reduction of hemoglobin (in long-term care), the increase in body mass index.

Уменьшает концентрацию фенитоина в плазме (на 20%).Decreases fenitoina concentration in plasma (20%).

Overdosing

There golovokrugeniem, Tremorom.lechenie : maintaining vital functions.

Precautions

Лечение проводится непрерывно и длительно, под постоянным контролем невропатолога, в т.ч.The treatment is an ongoing and long-term, continuously monitored neuropathologist, including and during drug remission. Is not recommended to use as a stand alone treatment. Increasing daily doses above 4 g does not increase efficiency, but increases the risk of adverse reactions. In patients with anamnesticescimi indications of the psychosi 218 s should be possible violations of behavioural responses at the beginning of treatment (aggression, psychotic episodes), and the therapy should begin with caution, using low doses and with careful monitoring. It should be borne in mind that children may develop so hyperactivity syndrome (giperkinesia, ajitation, causing concern). If any of the kidneys (lower Cl creatinine less than 60 ml / min) dose should be reduced. To prevent the development of 218 the syndrome should be a gradual decline doses over a period of two to four weeks. The decline, at least in the early treatmen 218 t of activities requiring greater attention and high coordination. The treatment must be periodically survey for the exclusion of patients, especially disorders of visual function (described sporadic neuritis and atrophy eye nerve).

Dosing and Administration

Inside, 1-2 times a day. Adults - initial dose 1 g / day, with heavy attacks, 2 g per day. Depending on the clin 218 ical response and endurance dose daily may increase or decrease by 0.5 and Best daily intake - G.detam 2-4, 40 mg / kg / day, with a further rise to 80 to 100 mg / kg, it is possible dose of 0.5 grams per week.

Literature

Walker M., Li DE, Sander J.W.A.S. Long term use of lamotrigine and vigabatrin in severe refractory epilepsy : audit of outcome / / Br. Med. J.-1996-V. 313-N-7066 P. 1184-1185.

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