Directory → Neurotropic funds → Противопаркинсоничес кие means → Duellin
This page is translated automatically with a help of Google Translate

Duellin

See also Carbidopa

Roman name

Duellin

Indications

Parkinson's disease, Parkinson's syndrome (due to carry encephalitis, cerebrovascular violations intoxication toxic substances, including monooksidom dioxide or manganese).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, zakratougolnaya glaucoma, severe anxiety, psychosis, melanoma (including suspected it), a disease Gentington, essencialny tremor, skin disease of unknown etiology, pregnancy, breast-feeding, age and 18 years of age.

Patient interaction

Do simpatomimetikov activity. Incompatible with MAO inhibitors. Simultaneous with the appointment of hypotensive drugs can cause postural hypotension, with tricyclic antidepressants, hypertension and hypertension diskineziu. Fenotiazina and reduce butirofenona effect antiholinergicakie substance reducyruut removals levodopa. If you are applying to levodopa beta-adrainostimulatorami, with the means of inhalation anaesthesia likely development of heart rhythm, with amantadine - potenziruty effect. Metildofa and levodopa can potenzirovti side effects of each other. Pyridoxine is kofactorom dofadekarboksilazy-enzyme responsible for the force on decarbauxilirovanie levodopa and education release. When a patient receiving levodopou (without inhibitors dofadekarboksilazy) there is a growing peripheral metabolism of levodopa, and a smaller number of passes through the GEB. Thus, pyridoxine reduces therapeutic effect levodopa, if not further appointed inhibitors dofadekarboksilazy peripheral. In appoint inhibitors dofadekarboksilazy daily levodopa dose can be reduced by 70-80% while maintaining the same clinical result. When coupled with the use of diazepam, fenitoinom, clofelinom, derivative tioksantena, papaverinom, rezerpinom, m-holinoblokatorami possible demotion противопаркинсоничес кого actions.

Precautions

Be wary (under close supervision) Designate patients with liver errosivno-yazvennah tract (stomach and / or duodenal ulcers), seizures pripadkah in history, myocardial infarct violations in the rhythm disorder, heart failure, diabetes, bronchial asthma, diseases of the endocrine, mental violations heavy violations of the liver or kidney. Leaving the treatment should be periodically monitored liver and kidney disorders and cardiovascular systems, the mental status of the patient. It should not be applied to secondary parkinsonizme because of antipsihoticeskih funds (doses). Termination therapy should gradually (to avoid the development of syndromic reminiscent neirolepticeski malignant syndrome : muscle rigidity, increased body temperature, increased CPK content in the serum). Control of patients who suddenly need to reduce drug overdose or suspension of his reception. In general anesthesia during surgery shall not reduce doses if a patient in a position to take drugs and the liquid inside. Using galotana and cyclopropane appointment Duellina ® end at least eight hours before the operation and after resuming operations in the same dose. Treatment MAO inhibitors should be discontinued at least 14 days prior to the appointment Duellina ®. Electoral MAO-B inhibitor (selegilin) can be used as a adjuvantny means for the treatment of levodopa. Since vsasavanii there is a competition between the aromatic amino acids and levodopa, during treatment should avoid the use of a large number of proteins. Side effects can be resolved temporary dose without interruption of treatment. Patients glaucoma amidst administered should regularly monitor the inner pressure. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

B. List at room temperature 15-25 ° C

Shelf life

3 years

The registration

015017/01-2003

All products of this group

0