Kognitiv

Roman name

Cognitiv

The composition and the form of

1 tablet coated liner contains selegilina hydrochloride 5 or 10 mg; blistere in 10 pcs. , in box 5 and 10 blisters.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract. C_max achieved within a short period of time. Associated with the plasma protein by 94%. Easily passes gistogematicalkie barriers, including GEB and accumulates in the tissues rich in lipids.

Indications

Parkinson's disease, parkinsonism.

Contraindications

Hypersensitivity, ekstrapiramidnye disorders unrelated to the lack of dopamine (essencialny tremor, trochaic Gentington), gastric ulcers and duodenal ulcers.

Side-Effects

In combination with levodopa, dizziness, headache, arousal, insomnia, fatigue, diskinesia, giperkinesia, gipotenzia, swelling, rash, dry mouth, nausea, constipation; Rarely anxiety sputannosti consciousness, psychosis, dizuria, dizziness, skin rashes; Rarely-increasing levels of liver enzymes, arterial hypertension, irregular, relapse of stomach ulcers.

Patient interaction

Incompatible with fluoksetinom, simpatomimetikami, preparations oppressive CNS, alcohol. Productivity increases levodopa (combined with perifericescimi decarboksilaza inhibitors). Amantadine and antiholinergicakie drugs increase the frequency of adverse events.

Precautions

Do not appoint patients receiving antidepression drugs (imipramine, fluoxetin). It should not be combined with levodopa with hypertension, tireotoxicose, feohromotsytome, uzkougolna glaucome, adenome prostate, tahiaritmii, heavy strokes, psihozah, dementia (progressive). It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

3 years

The registration

015209/01-2003

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