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Mirapex

See also Pramipexole

Roman name

Mirapex

The composition and the form of

1 tablet contains pramipeksola (in the form of dichloride monohydrate) 0.25 mg; Patients in the 90 pcs. , in a cardboard bundle bad one, or 1 mg; in a contour acheikova packing 10 pcs. , in a cardboard 3 bundle packaging.

Indications

Parkinson disease.

Pregnancy and lactation

In the case of pregnancy only if the benefit to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь.

Patient interaction

Zimetidin T_1/2 increases (40%); Ranitidine, diltiazem, triamteren, verapamil, quinidine and quinine reduce Cl (20%). Dopamine antagonists, including neiroleptiki, metoclopramide, reduce effectiveness.

Precautions

Patients should be alerted to the risks of hallucinations (especially older patients), the development Orthostatic hypotension (at the beginning of treatment, or if the dose), and episodes of sudden sleepiness. Be wary appoint patients with renal failure in history. In combination therapy with levodopa, it is necessary to reduce the dosage. Cancel the drug should continue one hour (at least).

Dosing and Administration

Inside. Initial dose at any stage of Parkinson's disease-0.375 mg / day in 3 reception, when necessary, may increase, but not more frequently than every 5-7 days of the scheme : in the first day, 0.375 mg / day, with the 2nd to 7th at 0.75 mg / day; supporting-dose of 1.5-4.5 mg / day in 3 Priema.u patients with renal insufficiency dose dependent on the Cl creatinine : if Cl creatinine greater than 60 mL / min for the 57 mg three times a day (maximum dose, 1.5 mg three times daily) 59 ml / min for 57 mg twice a day (a maximum of 1.5 mg twice a day), 15-34 ml / min, 0,125 mg once a day (a maximum of 1.5 mg once a day).

Storage conditions

List B. In the dark place at a temperature of 15-30 ° C

Shelf life

1.5 years

The registration

015908/01

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