Fort Deprim

Roman name

Deprim # forte

The composition and the form of

1 tablet, covered with skin contains 60 mg standardized extract of St. c 0.3 mg of hypericin; blistere in 10 pcs. , in box 3 blister.1 capsule - 425 mg standardized extract of St. c 0,75-1,3 mg total hypericin; in a contour acheikova packing 10 pcs.

Of drugs

Antidepressive, sedative. Ingibiruet MAO-A affects serotonin-, dofamin-, and GAMK- норадреналинергическ ую transfer to the central nervous system. Normalizes the functional status of central and autonomic nervous system.

Pharmacokinetics

According to the experiments on mice within 6 h absorbed 80% hypericin and 60% psevdogperitina. To extract containing 0.1% hypericin, C_max is 4.3 ng / ml, T1/2 24,8-26,5-p (for hypericin), and 2,7-30,6 ng / ml and 16,3-36 h respectively (for psevdogperitina).

Farmakodinamika

In vitro assays showed that the fraction extract wort containing mainly flavonoids, ingibiruet Katehol-o-metiltransferzu net hypericin - дофамин-бета-гидрокси лазу. Study IL1 bonding John extracts containing 0.15% of the total hypericin revealed a moderate degree of interaction with a set of GAMK_A / benzodiazepinovi рецептор/хлор-ионофор .

Clinical pharmacology

When taken vodno-spirtovogo extract herb species from healthy people in a daily dose equivalent to 0.53 mg of hypericin, there has been a substantial increase in the level of melatonin in the plasma at night.

Indications

Mild forms of neurotic depression (anxiety, fatigue, depression), psihoemozionale disorders, irritability and anxiety caused by mental fatigue.

Pregnancy and lactation

Perhaps only on doctor's prescription.

Contraindications

Hypersensitivity, the heavy depressed with suicidal attempts, treatment ziklosporinom, varfarinom etc. kumarinovmi antikoagulyantami, indinavir and other antiretroviral drugs; Age to 12 years.

Side-Effects

From the nervous system and sensory organs : fatigue, anxiety, sputannosti consciousness, the development of delusions in patients with bipolar Depressiei.so part of the intestine : gastrointestinal disorders, dry Rtu.allergicakie reaction : red skin, itching, photosensitization.

Patient interaction

It increases the activity of enzymes involved in the metabolism of drugs, including within two weeks after the lifting, and reduces the concentration of plasma and the effect racumin, cyclosporine, theofillina, indinavira, digoxin, oral contraceptives, tricyclic antidepressants (amitriptilina, nortriptilina). Together with the admission of other property and the subsequent lifting Deprima there is a danger of increasing concentration in the plasma and the possibility of side effects. Do side effects derivatives and triptan drugs inhibiting reverse takeover serotonin.

Overdosing

Symptoms : in recruitment capsules in doses exceeding recommended may increase side effects.

Precautions

The caution should appoint patients at the same time receiving preparations containing digoxin, theofillin, protevoepilepticalkie, oral contraceptives, antidepressants, triptana. During treatment, it is necessary to avoid intense ultraviolet exposure (prolonged sunbathing, fishing, etc.), receiving alcohol.

Dosing and Administration

Inside, before delivery, squeezed Vodoy.tabletki : adults and children older than 12 years, 1 tab. 3 times a day (for children over the age of six years - table 1-2. a day, morning and afternoon). Capsule : adults and children over 12 years of age-1 caps. 3 times a day at the same time. The dose may be increased to two caps. morning and Vecerom.minimalny course two weeks.

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