Directory → Neurotropic funds → Hypnotics funds
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The groupHypnotics of the current drugs of different chemical groups. Barbiturates, former long main diet drugs began to lose its leading position. However, increasingly the compounds benzodiazepinovogo number-nitrazepam, midazolam, temazepam, flurazepam, flunitrazepam, etc.
Barbiturates have a number of shortcomings. Caused by the dream is different from the natural : they make offensive sleep (sleeping) but changing its structure is the ratio of phases quickly (ironic, �есинхронизированног��) and the slow (Orthodox synchronized) sleep. Often, sleep is intermittent, with a lot of IDulcinea, nightmares. After it is prolonged drowsiness, weakness, coordination of movements, eye and other undesirable phenomenon. When reusing develops tolerance (addiction), and to eliminate the effect of the need to increase the dose. Large doses may suppress respiration, reduce AD (up to vascular collapse), lower body temperature, reduce diurez, etc. In some cases barbiturates have "paradoxical", the source, instead of calm and sleep, agitation. Could develop effect, the total insomnia with a reception from the market. One of the most negative manifestations of barbiturates-emergence at the time of physical and psychological dependence.
Hypnotics of the benzodiazepine (nitrazepam, etc.) have to some extent advantage over barbituratami is better postponed. But by nature caused sleep, or on the spin-off effects, they also do not meet the "physiological" requirements. All tranquilizers benzodiazepine group are to a greater or lesser degree, the sedate and offensive to sleep. The intensity of the action (sedative, anksioliticski, miorelaksirutego, etc.) different preparations of the group vary. The funds have expressed the most widespread effects include nitrazepam, triazolam, fenazepam, flurazepam, temazepam, etc. The mechanism of sleep produced essentially similar to tranquilizers this series. All of them are connected in the tissues of the brain with specific benzodiazepinovmi receptor. In recent years, these receptors are divided into subgroups (BOD_1 and BOD_2). Believed that the hypnotic effect is to troponostew Bd_1-retseptoram. Interaction with benzodiazepinovmi receptors activated by Gamk-retseptorov, which leads to inhibition of the functional activity of cells of the central nervous system. The importance to the nutritional effect is oppression activity of cells retikuliarna activating the brain stem.
There also sleep preparations new chemical groups (zopiclon, zolpidem). Of the well-known sleeping pills, the bromizoval (bromural).