Amobarbital

Chemical name

5-Этил-5-(3-метилбутил)-2, 4,6(1Н,3Н,5Н)-пиримидинтр��он (in the form of sodium salt)

Gross

C11-H18-N2-O3

Characteristics

The white crystalline powder, little soluble in water.

Of drugs

Drugs, the sedative, sleeping. Ingibiruet afferentne end in the cortex (including propulsion zones), amends the pair is weakness, drowsiness. Induzirovanny sleep characterized by the decrease rapid phase of sleep and sleep time. Induces system zitohroma P450 mikrosom liver. Quickly absorbed by any of the introduction. Speed removal of the stomach and injectable depot depends on the drug form (salt absorbed more acid solutions, the fastest solid substances), and in the appointment of the interior, and to eat the food (erh-intensive than after delivery). The blood is associated with proteins easily passes gistogematicalkie barriers. Penetrates into the brain, liver, kidneys and other organs. T_1/2 an average of 25 hours (varies within 16-40 hours). Treated biotransformation oxidation in the liver and digestive tract. Report mostly in the form of metabolites in urine. Step is a 45 to 60 min after administration of the interior, a bit faster, with the / m introduction and immediately, in the on / in the shop. Oppression CNS is sedaciei, sleep, analgeziei, anesthesia, coma and stop breathing.

Indications

Insomnia, agitation anxiety katatonicescie reaction, the reaction of negationism, premedikation.

Contraindications

Hypersensitivity (including from other derivative barbiturova acid), or manifestirutaya latentnaya porphyria in history expressed by liver dysfunction, obstructive respiratory disease, smoking, pregnancy, breast-feeding (at the end of treatment), children's age (up to 6 years).

Side-Effects

Gipoventilatia, dyspnoea, atelectasis, aetiology, gipotenzia, fear, nausea, vomiting, constipation, headache, fever, liver dysfunction, megaloblastnaya anaemia (with long-term use), the development of tolerance, addiction, the physical and mental dependence, the syndrome (arousal sputannosti consciousness giperkinesia, ataxy, CNS depression, nightmares, restlessness, anxiety, psychoses, hallucinations, insomnia, dizziness, thought disorder), allergic reaction (angioneuroticeski swelling, skin rashes, dermatitis exfoliativei).

Patient interaction

Impact concentration induces metabolism and the activity of anti proximity, oxidizing mikrosomalna the liver.

Overdosing

Symptoms (seen within 15 min) : CNS oppression, the absence or weakness reflexes, gipoventilatia, gipotenzia, hypothermia, pulmonary lung hemorrhagic blister in Nadavlivania.lechenie : washing stomach (with activated carbon), IVL, careful monitoring and maintenance of the vital functions, the normalization of the gas composition and blood electrolytes, Hepatology and gemoperfuzia.

Precautions

The progressively lower dose (in preventing and mitigating the effects of recurrent insomnia).

Dosing and Administration

Inside for 15-30 minutes before sleep, adults on the city 0.1-0.2

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