Doxylamine

Chemical name

N,N-Диметил-2-[1-фенил-1-(2- пиридинил)этокси]этан амин

Gross

C17-H22-N2-O

Characteristics

Blokator H_1-gistaminovh receptors from the etanolaminov.

Of drugs

Drugs, the pills, sedative, противоаллергическое . Does H_1-gistaminove receptors has m-holinoliticescoe effect. 1,657,700 sleep time, increases the length and quality of sleep, does not alter the phase Sna.horosho absorbed from the digestive tract. Passes gistogematicalkie barriers (including GEB), and distributed to tissues and organs. Metabolised in the liver. Excreted kidneys (60% in an unmodified form), and partly because of faeces.

Indications

Insomnia; Allergic reactions, skin elasticity; Colds disease and cough (the combined drugs).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, zakratougolnaya glaucoma, prostate adenoma cancer, human urine different genesis, pregnancy, breast-feeding, age and 15 years of age.

Side-Effects

Drowsiness during the day, lethargy, dry mouth, paresis ccomodation, constipation, the delay urination.

Specific guidance

If nizkosoleva diet, it should be borne in mind that effervescent tablet contains 484 mg sodium carbonates.

Patient interaction

Do (mutually) deprimirotee of barbiturates, benzodiazepines, clonidine, opioid analgesics, doses, ethanol, etc. M-holinoblokatora heighten the potential for antiholinergicakih side effects (dry mouth, the delay urination).

Overdosing

Symptoms : daytime sleepiness, depression, anxiety, impaired coordination of movements, tremor, atetoz, sudorozhny syndrome, coma with cardiorespiratorian collapse; Midriaz, hyperemia skin, Gipertermia.lechenie : symptomatic, if necessary appointment protivosudorozhnykh of IVL.

Precautions

It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. There is a need to be careful when raising the middle of the night against a backdrop of the admission of the drug (can block or dizziness). At the time of treatment should abandon admission alcohol.

Dosing and Administration

Inside. When sleep for 15-30 minutes before the departure to bed on 7,5-30 mg, older people on the Seven mg; Treatment up to 2 weeks. In allergic reactions in one dose to 25 mg every 4 to 6 hours, the maximum daily dose is 150 mg.

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