Flurazepam

Chemical name

7-Хлор-1-[2-(диэтиламино) этил]-5-(2-фторфенил)-1,3-��игидро-2H-1,4- benzodiazepin-2-on (and as dihydrochloride)

Gross

C21-H23-Cl-F-N3-O

Characteristics

Red means of a group of benzodiazepine derivatives. Flurazepama hydrochloride - bledno-jeltoe TNT connect very well rastvorimo in spirit rastvorimo well in the water.

Of drugs

Drugs, the pills, sedative. Interacts with specific receptors benzodiazepinovmi limbic system of the brain, increases Gamkergicakie mezhneironne Contakta.vazavaet sleep on the close to the physiologic, reduces the cerebellum, reducing probujdeni increases the duration of sleep. Effective in patients with recurrent insomnia; If there is a violation of habits contributing to the offensive sleep, as well as acute or chronic clinical situations for the rest of his sleep. In examining flurazepama laboratory sleep has been shown that it is effective for at least 28 nights Priema.posle intake of rapidly absorbed from the digestive tract and rapidly metabolized. After one reception C_max plasma is 30 to 60 minutes. Linking blood protein, 97%. Biotransformiroetsa into two metabolites : N_1-гидроксиэтилфлураз епам (determined in the blood during the first hours after receiving 30 mg and the 24 h) and N_1-dezalkilflurazepam-major metabolite, circulating in the blood, the concentration equilibrium is achieved in one week to 10 days after your receipt and 5-6 times higher than the concentrations found in the first 24 hours. T_1/2 of 2.3 hrs (flurazepam), 2-4 hrs (N_1-gidroxiatilflurazepam), 30-100 p (N_1-дезалкилфлуразепа��). Return with urine in the form of kongugata N_1-гидроксиэтилфлураз епама (22-55% of dose) and N _1-дезалкилфлуразепам�� (less than 1%). With the continuous koumouliruet admission in the form of метаболитов.Особенно��ти pharmacokinetics explain the fact that the vtoru-tretthew night after the start of treatment effectiveness flurazepama rising, and within one or two nights after receiving the cerebellum and the total time wakefulness may remain Umeneshennami.u newborns whose mothers took flurazepam for the treatment of insomnia (30 mg per night) for a period of 10 days before, observed hypotension, the absence of activity in the first four days of life (and in the blood of newborns diagnosed N _1-дезалкилфлуразепам) .

Indications

Violations of sleep (sleep difficulty, frequent night and / or early morning awakening).

Restrictions on the use of

Violation breathing, asthma patients during sleep and depressive state of the liver and / or kidney.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, the paradoxical reaction to the alcohol and / or sedation, pregnancy, breast-feeding, age and 18 years of age.

Side-Effects

From the nervous system and sensory organs : dizziness, headache, drowsiness during the day, weakness, ataxy, boltlivosti, anxiety, impaired memory and / or thinking that the reduction of concentration, nervousness, irritability, anxiety, euphoria, depression, smazannaya speech sputannosti consciousness, hallucinations, paradoxical reactions (including causing hyperactivity), impaired vision, pain in the eyes, Vkusa.so change the circulatory system and blood (blood, gemostaz) : heart, the pain in the chest, gipotenzia, lakopenia, Granulozitopenia.so part of the intestine : flatulence, cramps in the abdomen or stomach, diarrhoea phenomenon, nausea, vomiting, diarrhoea or constipation, dry mouth and increased slunootdelenie, �норексия.Аллергическ ие reactions : skin, Sapi.prochie : dizuria, increased sweating, difficulty breathing; raising ACT ALT, Bilirubina.vozmojna drug dependency, the syndrome (with a long reception) - see "Precautions."

Patient interaction

In a joint application with flurazepama PP with pills effect and the means oppressive central possible additive effect.

Overdosing

Symptoms : drowsiness, excessive sedative effect of consciousness and Koma.lechenie : the immediate scene stomach supporting therapy, monitoring vital functions. In developing an introduction barbiturates is not recommended. As a specific antidote used BZ antagonist flumazenil receptors (in the hospital).

Precautions

Be wary designated for chronic alcoholism and mental disorders (elevated risk of drug addiction), and depression (possibly increased symptoms), human liver and kidneys, in old age and weakened patients (elevated risk of overdose and the development of side effects of the central nervous system). Perhaps the Drug Dependence (with a long reception). Where sleep disturbance are of a temporary and permanent nature, it is usually enough to eliminate the appointment of funds for a short period of time. The use of pills for a long period of time is not shown. If necessary, a long-term means to eliminate possible only after the assessment of the state of Patienta.neobhodimo avoid abrupt cancellation of the drug and reduce the dose gradually. In a dramatic admission of a possible withdrawal syndrome (tremor, convulsions, abdominal or muscle cramp, dysphoria, insomnia), the most often appears after taking high doses or after prolonged Lechenia.vo treatment should refrain from activities that require greater attention and rapid mental and motor reactions. The treatment should not take other means, depressing central nervous system. No alcohol during treatment and for a few days after the meeting.

Dosing and Administration

Inside (at night). The dosage and duration of treatment set individually. Treatment should start with the smallest effective dose, the average dose for adults 15-30 mg, the elderly and immunocompromised patients is 15 mg. The duration of treatment averages 10 days.

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