Melatonin

Chemical name

N-[2-(5-Метокси-1H-индол-3-��л)этил]ацетамид

Gross

C13-H16-N2-O2

Characteristics

Synthetic hormone analogue of the pineal gland (epiphysis).

Of drugs

The drugs-adaptogennoe, nursing and antioxidant. It stops the secretion gonadotropinov, to a lesser extent, other hormones adenogipofiza - kortikotropina, tireotropina, somatotropina. Normalizes zircadne rhythms. Increases concentration of GABA in the CNS and serotonin in the brain average and Hypothalamus, modifies activity piridoksalkinaza involved in the synthesis of GABA, dopamine and serotonin. Regulates sleep cycle-vigil, daily changes locomotor activity and body temperature, a positive impact on интеллектуально-мнес��ические of the brain, �моционально-личностн ую area. Does the biological rhythm and normalization night sleep. Improves quality of sleep, reduces the frequency of attacks headaches, dizziness, improves the mood. Makes sleeping reduces the number of night probujdeni improves fitness after the morning awakening, it is feeling weak, razbitosti and fatigue in awakening. Makes got brighter and emotionally rich. Organism adapts to rapid changes in time zones, reduces stress reaction regulates neuroendocrine function. Has immunostimulirute and antioxidant properties, prevents atherosclerosis and cancer. Most expressed the support for long expressed violations Sna.pri ingestion rapidly and completely absorbed easily passes gistogematicalkie barriers, including GEB. There is a short T_1/2 quickly withdrawn from the body.

Indications

Insomnia, fatigue, stress syndrome, desinhronoz.

Pregnancy and lactation

Contraindicated in pregnancy. During treatment should stop breastfeeding.

Contraindications

Hypersensitivity, chronic renal failure, allergies, auto-immune diseases, chlamydia, leukaemia, lymphoma, mieloma, epilepsy, diabetes, pregnancy, breast-feeding.

Side-Effects

Headache, nausea, vomiting, diarrhea, allergic reactions.

Specific guidance

It is not bright at the time of treatment.

Patient interaction

Do effect (mutually) products oppressive CNS and бета-адреноблокаторо��. Incompatible with MAO inhibitors, glukokortikoidami, ziklosporinom.

Precautions

Not recommended simultaneous reception NPVS (acetylsalicylic acid ibuprofenom) with the means oppressive CNS and бета-адреноблокатора��и. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. There is a need to inform women who want to get pregnant, having a weak drug control action.

Dosing and Administration

Inside, as 1-5 mg once a day for one hour before sleep.

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