Nitrazepam

Chemical name

1,3-Дигидро-7-нитро-5-фен ил-2Н-1,4-бензодиазепин- 2-он

Gross

C15-H11-N3-O3

Characteristics

Brown or yellow to greenish white crystalline powder. Virtually nerastvorim water, little soluble in alcohol and ether.

Of drugs

Drugs, the pills, sedative, protivosudorozhnoe, anxiolytic, miorelaksirutee (central). Interacts with specific receptors benzodiazepinovmi ГАМК-бензодиазепин-хл орионофорного complex activates it increases sensitivity to mediatoru contributes to the opening of the ion channel and increases the braking effect GABA in the CNS. Decreases anxiety cells in the subcortical areas of the brain (limbical system Diencephalon, dystonia), the cerebellum, crust, etc. CNS divisions. The importance for a snotvorna activity is oppression cells retikuliarna formations barrel head Mozga.posle intake of fast and complete skin, bioavailability about 80%. C_max achieved in 2-3 hours Linking plasma protein level (87%). It passes through gistogematicalkie barriers, including GEB, placental, enters the breast milk. T_1/2 - 16-48 h. Treated biotransformation in the liver by nitrogroup reduction and subsequent acetylation education azetilproizvodnykh inactive. Report the news, mostly in the form of metabolites, about 5% in unchanged Vide.snotvornyi effect develops through 20-45 minutes after administration and lasts for 6-8 hours, the easier sleep increases the depth and duration of sleep.

Indications

Insomnia, neurotic (neurozopodobne) disorders, some forms of stroke convulsions (especially in children), premedikation undergoing surgery.

Contraindications

Гиперчувствительност ь (including from other benzodiazepines), male, zakratougolnaya glaucoma, a breach of the kidneys and liver, medication, drug or alcohol dependency, pregnancy, breast-feeding (must stop breastfeeding).

Side-Effects

Drowsiness, weakness, a sense of fatigue (on the day following the reception), dizziness, headache, slow mental and motor reactions sputannosti speech, weakness, including muscle, ataxy, reduced libido, tachycardia, respiratory depression (rare), nausea and diarrhoea etc. disorders, allergic reactions (skin itching, rash).

Patient interaction

Sedatives, hypnotics, psychotropic substances, alcohol added effect противоэпилептически е (phenytoin and barbiturates) - toxicity. Zimetidin, oral contraceptives estrogensoderjaschie slow metabolism and increase concentration in the blood.

Precautions

With long-term use may develop addiction. Avoid alcohol and to refrain from calling for greater attention and speed of mental and motor reactions during treatment.

Dosing and Administration

Inside, at night, adults, 5-10 mg, the maximum single dose of 20 mg, older 2.5-5 mg within 7 to 10 days, children with mioclauniceskih fits-0.3-1 mg / kg / day in three reception.

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