Signopam

Roman name

Signopam #

The composition and the form of

1 tablet contains temazepama 10 mg; blistere in 20 pcs. , in the box one blister.

Of drugs

Anxiolytic, sedative, sleeping, miorelaksirutee. Modulating sensitivity Gamkergicakih receptors increases their affinity for mediatoru (GABA), and increases the braking process in the CNS.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. C_max achieved through 1.5 hours at 669-982 ng / J Associated with the blood supply by 96%. Passes through GEB and placental barrier. Fully biotransformiroetsa in the liver to inactive metabolites. T_1/2 - 8-12 hours Write mainly with urine in the form of inactive glukuronidov.

Farmakodinamika

There are many structures of central nervous system (primarily for limbicescuu system and dystonia). Do braking influence GABA in the cortex, gippocampe, cerebellum, spinal cord, etc., thereby reducing the various groups neuronal : adrenergicakih, holinergicakih, dofaminergicakih and serotoninergicakih.

Indications

Sleep disorders (difficulty falling asleep, night or early awakening), somatic and mental illness (depression, arterial hypertension), premedikation.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, violations of respiratory central origin, severe respiratory distress, infants, glaucoma, human consciousness pregnancy.

Side-Effects

Depression, drowsiness, dizziness, headache, fatigue, weakness, nervousness, fear, euphoria, the disorientation, the weakening of memory, concentration, slowing of reaction, the disorder, indiscriminate speech dry mucous membranes mouth, nausea, diarrhoea, feeling discomfort in the abdominal cavity gipotenzia, lowering pill, a breach of urination, neutropenia, jeltushnosti skin, Strange reaction, the mental institute, insomnia, fear (call for the elimination of the drug), allergic skin manifestations.

Patient interaction

Effect increase barbiturates gipotenzivee preparations neiroleptiki, antidepressants, anti-convulsants, narcotic analgesics, alcohol; Weaken - oral contraceptives.

Precautions

Be wary appoint patients older (recommended 1 / 2 dose), and human liver and kidneys. During treatment, and within 3 days after its completion not use alcohol. In order to prevent the development of mental disorders and withdrawal syndrome, especially after long-term therapy, the dosage should be gradually reduced (under the supervision of a doctor).

Dosing and Administration

Sleep disorders : inside, adults 10 to 20 mg for 30 minutes before Sna.tagelae of insomnia : 30 Mg.premedikation : for 30-60 min before surgery or diagnostic procedures - 20-40 mg.

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