Zolpidem

Chemical name

N,N,6-Триметил-2-(4-метилф енил)имидазоло[1,2-a]пир идин-3-ацетамид (and in the form of tartrate)

Gross

C19-H21-N3-O

Characteristics

White or no white crystalline powder sparingly soluble in water, alcohol and propilenglikole.

Of drugs

Drugs, the pills. Prosecutor omega_1 receptors in alfa-subjedinice Gamk-retseptornah complexes located in the IV sensorno-mothornykh plates of crust brain retikuliarnah divisions black substance, vision becomes ventralnogo talamicski complex bridge pale balls, etc. Interaction with omega-retseptorami leads to the opening of neironalnah ionoformnah channels for Hlora.bystro absorbed from the digestive tract, bioavailability is about 70% C_max admission to 10 mg of 58-272 ng / ml and is a 1.6-hour Linking plasma protein-92.5%. T_1/2 - 1,4-4,5 hours Is the inactive metabolites and excreted from the body mainly through the kidney. It has the ability to cumulation. In tranzitorna insomnia in older patients improves the ability to fall asleep, increasing the duration and improves the quality of sleep and reduces the number of probujdeni. Lengthens the phase II sleep and deep sleep (III and IV stage). In chronic insomnia improves the ability to fall asleep (within 4 weeks of treatment), but had little impact on the frequency probujdeni. Syndrome abolishing expressed only in older patients with a dose exceeding recommended.

Indications

Insomnia (anomalous, tranzitornaya, chronic).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, acute or severe respiratory distress, infants, severe violations of the liver, pregnancy, breast-feeding, child age (up to 15 years).

Side-Effects

Daytime drowsiness, anterogradnaya amnesia astenization, headache, dizziness, sputannosti consciousness, visual impairment, diplopia, euphoria change walking, and behavioral reactions (aggressiveness, hallucinations), nightmares, pain in the abdomen, icota, nausea, vomiting, diarrhoea, skin rashes and itching, drug dependency (with long-term use).

Patient interaction

Potenziruet deprimiruty effects of narcotic analgesics, barbiturates, antidepressants (with a sedative component), Neuroleptics, antigistaminnah drugs, alcohol. Coupled with imipraminom or hlorpromazinom the additive. Flumazenil eliminates widespread influence.

Overdosing

Symptoms : violation of consciousness (on the polubessoznatelnogo to light coma), cardiovascular and respiratory Narushenia.lechenie : the immediate scene stomach, as an antidote to flumazenil. Showed monitoring of the vital functions (breathing, pulse, AD, etc.), if necessary, symptomatic therapy. The institute should refrain from imposing any sedated. Dialysis weak.

Precautions

Because sleep disturbance may be a harbinger of serious physical and mental illnesses, symptomatic treatment of insomnia can be initiated only after a detailed survey of the patient. During treatment should strive to create an enabling environment for sleep. If this recommendation, or the frequent use of uncontrolled high doses increase the risk of drug dependence. If any liver product appointed polovinnah doses. In the terminal stage renal failure can be appointed under normal doses of adequate monitoring. Older people should receive only small doses (required careful monitoring). During treatment, it is necessary to abandon the admission of alcohol. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, immediately before bedtime (already lying in bed), one. Before 65-10 mg, over 65 years, 5 mg, if necessary, no more than 10 mg. The course of treatment for abnormal sleep for 2-5 days, tranzitorna no more than four weeks.

Directory → Neurotropic funds → Hypnotics funds → Zolpidem