Tetrazepam

Chemical name

7-Хлор-5-(1-циклогексен-1 -ил)-1,3-дигидро-1-метил-2 H-1,4-бензодиазепин-2-он

Gross

C16-H17-Cl-N2-O

Of drugs

The drugs-miorelaksirutee (central). Benzodiazepinove stimulates receptors increases the sensitivity to Gamk-retseptorov mediatoru and enhances braking influence GABA in the CNS. Decreases anxiety subcortical structures of the brain (the protivosudorozhnoe), down polisinapticalkie spinale though. Reduces emotional stress reduces anxiety, fear, anxiety (anxiolytic and sedative effect). Passes through tissue barriers, including GEB. T_1/2 - 14-16 h.

Indications

• contracture, neurological contracture of the spasm, wryneck, myofasciitis accompanied by sore expressed syndrome, the pain in his back and lower back, pain syndrome in pathology tendons (epikondilit, tendowaginit) and the joints, for kinezogidrotherapii.

Pregnancy and lactation

Contraindicated in pregnancy (especially in the first trimester). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, respiratory distress, infants, pregnancy (especially I trimester), breast-feeding.

Side-Effects

Drowsiness, dizziness, euphoria paradoxical reaction (irritability, aggressiveness), muscle weakness, ataxy, skin rashes, itching of the skin; Quick aside : irritability, anxiety, mialgia, tremor, insomnia, nightmares, nausea, vomiting, convulsions, the slowdown in the rate of reaction, a sense of fatigue.

Patient interaction

Do (mutually) effects miorelaksantov, Neuroleptics, tranquilizers, tricyclic antidepressants, alcohol, sedatives and tranquilizers funds.

Precautions

It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. At the time of treatment must abstain from alcohol.

Dosing and Administration

Inside, in a hospital in a dose of 50 mg per night; Gradually increase the dose of 25-50 mg, distributing it to a number of techniques to achieve effective therapeutic dose of 150 mg 3 admission; If necessary, 300-400 mg / sut. The outpatient treatment initial dose is 25 mg evening, gradually increase the dose to 25 mg, distributing it to a few events; Effective dose, 75 mg / sut. For children 4 mg / kg / day in a few receptions. Older patients - 1 / 2 doses. Cancel preparation must take place gradually. Kinezogidrotherapia-50 mg per hour to session.

Directory → Neurotropic funds → Funds affecting neuromuscular transmission → Tetrazepam