Tizanidine

Chemical name

5-Хлор-N-(4,5-дигидро-1H-им идазол-2-ил)-2,1,3-бензот��адиазол-4-амин (as hydrochloride)

Gross

C9-H8-Cl-N5-S

Characteristics

White or slightly yellow crystalline powder.

Of drugs

The drugs-miorelaksirutee (central). Institute альфа_2-адренергическ��е receptors, mainly at the level of the spinal cord; reduces emissions incident amino acids interim neuronal spinal cord selectively suppresses polisinapticalkie mechanisms responsible for muscle gipertonus. Skeletnuu relaxes muscles for chronic conditions spastic spinal and cerebral origin eliminates acute painful muscle cramp and clauniceskie convulsions. Impact resistance in the muscle passive movements, the increase of arbitrary muscle Sokreatmeni.posle reception inside quickly and almost completely absorbed. C_max achieved in 1-2 hours The plasma protein binds 30%. Biotransformiroetsa in the liver to inactive or low metabolites. Place 70% of the urine. T_1/2 for 3-5 hours

Indications

The painful muscle cramps in diseases of the vertebral column (including bone, spondilez, siringomieliu, gemiplegiu, thoracic and lumbar disorders), after surgery for the slipped disc or osteoartrita thighs, Spasticity and pain caused by neurological diseases : multiple sclerosis, chronic mielopatia, degenerative diseases spinal cord of cerebral circulation, stroke, head injuries, cerebral palsy, convulsions central origin.

Contraindications

Hypersensitivity expressed lack of liver and kidney failure, pregnancy, breast-feeding (at the end of treatment), children's age.

Side-Effects

Mood, a sense of fatigue, dizziness or vertigo, muscle weakness, anxiety, sleep disorders, hallucinations, slight decrease AD (at low doses), or arterial hypertension, aetiology, dry mouth, nausea, stomach disorders, a temporary increase in transaminaz in whey.

Patient interaction

Antigipertenzivee drugs, including dioretiki reinforce hypotension and bradycardia. Alcohol and sedatives deepen deprimiruty effect.

Overdosing

Symptoms : nausea, vomiting, arterial gipotenzia, dizziness, cramps, breathing problems, Koma.lechenie : washing stomach reception activated carbons big diurez, maintaining vital functions.

Precautions

A periodic monitoring of liver and the kidneys and reduces doses in their deterioration. The increasing transaminaz activity in the blood calls for the end of the reception. Because of the possible wasting and weakness that limit that persons whose work requires quick physical and mental reaction (operators, drivers of motor vehicles, etc.).

Dosing and Administration

Inside, as 2-4 mg three times a day, in severe cases, an additional 2 to 4 mg per night. In neurologicaki of spastic conditions initial dose should not exceed 5 mg per day in March reception, with a gradual increase of 2-4 mg at intervals of 3-4 days, up to a week. Optimal therapeutic effect is achieved with the dose of 12-24 mg / day for 3-4 reception at regular intervals (not more than 36 mg per day).

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