Becaplermin

Characteristics

Rekombinantny human trombozitarnyi growth, a method for recombinant Dnk-tehnologii of kletok-produzenta-strain yeast Saccharomyces cerevisiae, in the genetic apparatus which built gene V-tsepi trombozitarnogo factor Rosta.predstavlet a gomodimer consisting of two identical 40b conversations involving disulfidnami bridges.

Of drugs

The drugs-reparativoe. And such activity is trombozitarnogo endogenous growth factors : increases the hemotaksisa and proliferatiou cells involved in the reparation process, thus formation of granulation tissue in diabetic Yazve.kliniceski effect bekaplermina with open wounds of joints, tendons, ligaments, bones in a person yet to be defined. However, in studies on animals revealed histological changes indicating growth stimulation connective tissue and accelerate remodelirovania Kostei.issledovani cancer-causing in humans and animals, as well as the impact on the reproductive function in animals did not. There has been mutagennogo actions tests in vitro and in Vivo.sistemnaya absorption of a local application of the low.

Indications

Neiropaticalkie diabetic ulcer lower limbs involving subcutaneous or deeper tissue with adequate circulation (additional therapy combined with the best protivoyazvennami procedures, the primary surgical treatment OXISEPT therapy and unloading limbs).

Restrictions on the use of

Pregnancy, breast feeding, child age (safety and efficacy of the use of children under 16 years of age to be determined).

Pregnancy and lactation

Be wary of pregnancy (adequate and well-controlled studies in pregnant women did not), and breast milk (no data on the penetration of breast milk).

Contraindications

Hypersensitivity, incl. the paraben and metarezolu; skin neoplasms at the site of the gel.

Side-Effects

Local eritematosnaya rash (2%).

Specific guidance

Not recommended not to the wounds healing primary defect because gel is not sterile.

Precautions

During treatment of a regular (every 1-2 weeks), medical follow-up for the timely conversion of the gel caused depending on the cancer. If, within 10 weeks surface area of the ulcer is decreased by 30% or over 20 weeks showed complete healing, we need to reconsider the tactics treatment.

Dosing and Administration

External, once a day, at a monthly rate of 0.25 cm column gel (for liquid containing 15 g) at 1 cm ^ 2 of cancer. The formula for calculating the dose : ulcer length x width ulcer : 4. Number gel otmeraut after his steel net is not absorptive surface (such as paper). The desired amount of gel swab or spatelem moved to the area canker spread to the continuous thin film thickness of approximately 1.5 mm and placed H.6 bandage Pro 0.9% solution of sodium chloride. After 12 h cast off, remaining gel removes water or 0.9% solution of sodium chloride and placed wet plaster, including with the 0.9% solution of sodium chloride prior to the next application (12 h). The course of treatment is 20 weeks.

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