Silibinin

Chemical name

3,5,7-Тригидрокси-2-[3-(4-г��дрокси-3-метоксифенил )-2-гиидроксиметил-1,4-б��нздиоксан-6-ил]-4-хрома нон

Gross

C25-H22-O10

Of drugs

The drugs-gepatoproteguoe. Interacts with free radicals in the liver and translate them into less toxic compounds. Interrupting the peroxide oxidation of lipids, the continued destruction of cell structures. The damaged gepatocitah stimulates synthesis of structural and functional proteins and phospholipids (by specific stimulation Rnk-polimeraza A), stabilizes the cell membrane, prevents loss of cells (transaminaz) accelerates regeneration of liver cells. It stops entry into cells gepatotoksicskih some substances (poison mushroom dull grebes). Absorption low. Treated entero-pechenocna circulation. Metabolised in the liver by conjugation, T_1/2-6 pm Excretion predominantly with jelchew in glukuronidov and sulphate. Not koumouliruet. After repeated intake of 140 mg three times a day is a stable level of the jelchew. Improves overall patients with liver diseases, reduces subjective complaints normalizes laboratory indicators (transaminaz activity, gamma-glutamiltransferzy, alkaline phosphatase level cium). Prolonged use reliably increases the survival of patients with cirrhosis of the liver.

Indications

Toxic liver damage (alcoholism, intoxication galogenirovannami hydrocarbons, heavy metals, medicinal liver damage), chronic hepatitis, cirrhosis (composed of combination therapy), a breach of lipid exchange.

Contraindications

Гиперчувствительност ь.

Side-Effects

Diarrhoea, allergic reactions.

Specific guidance

Solution reception inside may be nominated sick diabetics, because it does not contain glucose.

Dosing and Administration

Inside, the food with liquid squeezed small amount of water. To treat heavy losses liver appoint 0.14 g three times a day, and then 0.14 g twice a day, in less severe cases, and for maintenance therapy for 0.07 g three times a day. Patients older children and preferable to use solution for oral use : with heavy liver problems adult-1 measuring teaspoonful 4 times a day, the children on one measuring teaspoonful three times a day; For the maintenance therapy three times a day : adults-1 measuring teaspoonful, children 1 / 2 measuring spoons.

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