Akrilanz

Roman name

Akrilans

The composition and the form of

1 capsule contains lansoprazola 0.03 g; in a contour acheikova packing 10 pcs. , in a cardboard bundle two packaging.

Of drugs

Protivoyazvennoe. Does the final stage of hydrochloric acid. For high lipophilicity easily penetrate cells parietalnae stomach. In parietalnah bone cancer cells transformed into an active form, sulfenamid irreversibly interact with Sh-groupami H ^ +-K + ^ -atfaza (proton pump). Decreases basal and stimulirovannuyu (regardless of the nature of irritant) secretion. Provides zitoproteguoe action increases the secretion of bicarbonate. Inhibition secreting hydrochloric acid at the dose of 30 mg is 80-97%. No impact on motoriku stomach. Ingibiruty effect increased in the first 4 days of therapy. Secretornaya activity restored in 3-4 days after application.

Pharmacokinetics

Absorption is high, eating reduces the absorption and bioavailability. After intake of 30 mg C_max (0,75-1,15 mg / l) is a 1.5-hour Linking blood plasma 97,7-99,4%. T_1/2 - 1.3 hours Metabolised in the "first pass" through the liver. Excreted memory (in the form of metabolites), 14-23%, and gastrointestinal. Patients with liver failure, and in older patients is slowing down.

Indications

Ulcers disease stomach and duodenal ulcers, reflux-ezofagit; Erosivno-azwenne defeat stomach and duodenal ulcer associated with hosting NPVS, stress ulcers, eradikation Helicobacter pylori (combined treatment), syndrome Zollinger-Ellison.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, kidney and / or liver failure, pregnancy, breast-feeding.

Side-Effects

Headache, dizziness, drowsiness, depression, diarrhoea, stomachache, constipation, pharyngitis, rhinitis, mialgia, allergic reactions, including skin rashes.

Specific guidance

Before treatment to rule out a malignant tumor in the upper gastrointestinal divisions (drug may mask the symptoms and make a diagnosis).

Patient interaction

Wrinkles eliminatiu PP, metaboliziruthan in the liver by mikrosomalnogo oxidation (including diazepam, phenytoin, indirect combined). Antatsida slow and reduce removals.

Dosing and Administration

Inside, capsules should swallow whole without Razjevwati.yazvennaya disease duodenal ulcer in the phase of deterioration : 0.03 g / day over a period of two to four weeks (in resistant cases up to 0.06 g / day). Ulcers stomach disease in the phase of deterioration and erosivno-yazate ezofagit : 0,03-0,6 g / day for a 4-8 defeat Ned.erosivno-azwenne intestine caused by the reception NPVS : 0.03 g / day for a 4-8 Ned.eradikation Helicobacter pylori : the 0.03 grams twice a day for 10 to 14 days in combination with antibacterial �редствами.Противорец идивное treating ulcers stomach and duodenal ulcers : 0.03 �/сут.Противорецидивн��е reflux-ezofaguita treatment : 0.03 g / day for a long time (up to 6 months). Syndrome Zollinger-Ellison : dose individually picked up to the level of basal secreta less than 10 mmol / h.

Storage conditions

caps. : List B. In dry the dark place at a temperature of no higher than 20 ° C

Shelf life

caps. : 2 grams.

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