Lithium fluoride

Characteristics

Clear crystals or white crystalline powder, soluble in 25 parts of water.

Of drugs

Drugs, the lack of complementary fluorine, protivokariosnoe, ingibirutee bone resorption. Fluorine ions stabilize calcium in the process of mineralization, replacing gidroksilnuyu group crystals apathitov education poorly soluble ftorapatita (density makes solid tissue). Induces Osteogenesis by osteoblastov stimulation. Decreases bone resorption increases its resistance to the action osteoclastov, increases bone mass. Is penetration fluorine in the tooth enamel, stimulates maturity, and the strength of enamel warn development of caries. Has bactericidal activity against kariesogenna microflora, reduces production of acids, in particular Molocna.pri ingestion well absorbed (93-97% fluorine), regardless of the meal. C_max plasma achieved within 4 hours Any dose of 50% revenue fluorine accumulate in solid tissues tooth and bone. Not involved in the mineralization fluoride display memory.

Indications

Osteoporosis : primary (postmenopauzalny, presenilny, senilny, idiopathic), steroidnyi (prevention and treatment); Local osteopathy, prevention of caries in children and adults, with the content in drinking water fluoride below 0.6 mg / J

Contraindications

For system applications : views of the kidney or liver, worsening ulcers stomach or duodenal ulcer, pregnancy, breast-feeding (at the time of application is required abandonment of breastfeeding), children up to age 6 months, 3 years, 6 or 14 years (depending on the form of drug and dose).

Side-Effects

The systems use : diarrhoea phenomenon pain in the lower extremities and joints, increased fatigue, weakness, headache, osteoscleros, ectopica calcification (especially when combined with vitamin D or A), hypothyroidism, idyoshinkrazia, allergic reactions (skin rashes, etc.).

Specific guidance

Increased alkaline phosphatase shows the effect.

Patient interaction

Ions of magnesium and aluminium down induction (forming poorly soluble compounds). Antatsida less efficient (recommended them for two hours before receiving sodium fluoride). Vitamins A and D are ectopicescoy calzificace.

Overdosing

Symptoms : slezotechenie, gipersalivacia, nausea, anorexia, krovanistaya diarrhoea and vomiting, pain in the abdomen and lower extremities and joints, narrowing pupils, impaired vision, weakness, male, tremor, convulsions, hyperthermia, pulse frequency, gipotenzia; Possible death (respiratory distress and stops breathing). The flow of long-hypothyroidism, in the period of teeth-fluorosis (the process of atherosclerosis and white, a yellow, brown and flat patches ispehrennosti, increasing fragility and abrasion of teeth). Treatment : immediate excessive amounts of liquid and calcium (calcium solution glukonata or lactate, milk) for the deposition of fluoride induction vomiting, Installation gastric lavage zakislenna water, or 1% solution of calcium chloride, a salt laxatives (30 g sodium sulfate), in / with the introduction of electrolytes (20 ml of 20% solution of calcium glukonata), vitamin preparations symptomatic therapy, monitoring the level of calcium in the blood; Hepatology possible.

Precautions

Intermittent treatment is recommended when there artralgi against the backdrop of an ongoing drug therapy. Applications for children under six years of age requires special monitoring. In patients with blood diseases during therapy recommended regular blood tests. The system will require that an annual X-ray examination to evaluate the effectiveness of therapy and decide to continue treatment, as well as for the early identification of fluorosis. In choosing dosage should consider the contents of fluoride in drinking water. To achieve adequate mineralization bone should further ensure that the body of calcium (1.0-1.5 g / day), and magnesium.

Dosing and Administration

The locomotive inside the 0,015-0,02 g 3-4 times a day every day, the long-term (1-4 years) permanently or rates to 3 months treatment, 2-3 months break. To prevent osteoporosis steroid 1 table. per day. To prevent caries during the entire period of teeth : children from 2 to 6 years into lengthy courses of tablets 0.0011 grams over six years - 0.0022 g once a day; Over 16 years - mouth rinse 0.05% solution of the food and brushing teeth.

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